Beca Francisco, Santos Renata, Vieira Daniella, Zeferino Luiz, Dufloth Rozany, Schmitt Fernando
IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal; Department of Medical Oncology, Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA, USA.
Faculty of Medicine, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.
Pathol Res Pract. 2014 Sep;210(9):571-5. doi: 10.1016/j.prp.2014.05.011. Epub 2014 May 22.
Despite the remarkable improvements in breast cancer (BC) characterization, accurate prediction of BC clinical behavior is often still difficult to achieve. Some studies have investigated the association between the molecular subtype, namely the basal-like BC and the pattern of relapse, however only few investigated the association between relapse pattern and immunohistochemical defined triple-negative breast cancers (TNBCs). The aim of this study was to evaluate the pattern of relapse in patients with TNBC, namely the primary distant relapse site. One-hundred twenty nine (129) invasive breast carcinomas with follow-up information were classified according to the molecular subtype using immunohistochemistry for ER, PgR and Her2. The association between TNBC and distant relapse primary site was analyzed by logistic regression. Using multivariate logistic regression analysis patients with TNBC displayed only 0.09 (95% CI: 0.00-0.74; p=0.02) the odds of the non-TNBC patients of developing bone primary relapse. Regarding visceral and lymph-node relapse, no differences between in this cohort were found. Though classically regarded as aggressive tumors, TNBCs rarely development primary relapse in bone when compared to non-TNBC, a clinical relevant fact when investigating a metastasis of an occult or non-sampled primary BC.
尽管乳腺癌（BC）的特征有了显著改善，但准确预测BC的临床行为往往仍难以实现。一些研究调查了分子亚型（即基底样BC）与复发模式之间的关联，然而只有少数研究调查了复发模式与免疫组化定义的三阴性乳腺癌（TNBC）之间的关联。本研究的目的是评估TNBC患者的复发模式，即远处复发的原发部位。利用免疫组化检测雌激素受体（ER）、孕激素受体（PgR）和人表皮生长因子受体2（Her2），根据分子亚型对129例有随访信息的浸润性乳腺癌进行分类。通过逻辑回归分析TNBC与远处复发原发部位之间的关联。使用多变量逻辑回归分析，TNBC患者发生骨原发复发的几率仅为非TNBC患者的0.09（95%可信区间：0.00-0.74；p=0.02）。关于内脏和淋巴结复发，该队列中未发现差异。尽管TNBC传统上被认为是侵袭性肿瘤，但与非TNBC相比，TNBC很少发生骨原发复发，这在研究隐匿性或未取样的原发性BC转移时是一个临床相关事实。
