Burtonboy G, Beckers A, Rodhain J, Bazin H, Lamy M E
J Natl Cancer Inst. 1978 Aug;61(2):477-84.
Fifteen spontaneous immunocytomas originating in the ileocecal lymph nodes of Lou/C/Wsl rats were studied by means of electron microscopy. The histology was characteristic, the tumor being formed by an accumulation of large, rounded cells with slightly eccentric ovoid nuclei, large nucleoli, and finely condensed chromatin along the nuclear walls; the cytoplasma was rich in polyribosomes. The appearance of the rough endoplasmic reticulum was apparently the same whether or not the tumor was secretory. Its development varied from one cell to another, and in only a small proportion of cells did it attain any considerable volume. In all the tumors examined, we noted the presence of intracisternal A-particles. In its morphology, the rat immunocytoma resembled the plasmacytomas induced in mice, and it also resembled certain human tumors such as Burkitt's lymphoma.
运用电子显微镜对起源于Lou/C/Wsl大鼠回盲部淋巴结的15个自发性免疫细胞瘤进行了研究。组织学特征明显，肿瘤由大的圆形细胞聚集形成，细胞核略呈偏心椭圆形，核仁大，核壁周围染色质细而凝聚；细胞质富含多聚核糖体。无论肿瘤是否具有分泌功能，粗面内质网的外观显然相同。其发育在不同细胞间存在差异，只有一小部分细胞的粗面内质网体积可观。在所有检查的肿瘤中，我们都发现了核内池A颗粒。大鼠免疫细胞瘤在形态上类似于小鼠诱导产生的浆细胞瘤，也类似于某些人类肿瘤，如伯基特淋巴瘤。
