Yale University, School of Medicine, Department of Psychiatry, 34 Park St, New Haven, CT, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Feb 6;73:36-40. doi: 10.1016/j.pnpbp.2016.10.002. Epub 2016 Oct 20.
Histaminergic dysfunction has been recently linked to tic disorders and to aberrant striatal function. There is a particular interest in the histamine 3 receptor (H3R) due to its clinical implications for treating multiple disorders and its high expression in the brain. Striatal histamine (HA) modulates through the H3R in complex ways the release of striatal neurotransmitters into this brain region. The H3R has been classically described to be coupled to G, although there is evidence that revealed that striatal H3R forms heteromers with the dopamine receptors 1 and 2 in the medium spiny neurons (MSNs) than changes this signaling. Moreover, new data described for the first time a complete, segregated and time dependent signaling after H3R activation in the two types of MSNs (D1R-MSNs and D2R-MSNs). The aim of this review is to update the role of HA and H3R in striatal function at a molecular and signaling levels.
组胺能功能障碍最近与抽动障碍和纹状体功能异常有关。由于组胺 3 受体 (H3R) 具有治疗多种疾病的临床意义及其在大脑中的高表达，因此人们对其特别感兴趣。纹状体组胺 (HA) 通过 H3R 以复杂的方式调节纹状体神经递质在该脑区的释放。H3R 经典上被描述为与 G 偶联，尽管有证据表明，纹状体 H3R 与中脑多巴胺受体 1 和 2 在中脑多巴胺神经元 (MSNs) 中形成异源二聚体，从而改变这种信号。此外，新的数据首次描述了 H3R 在两种类型的 MSNs（D1R-MSNs 和 D2R-MSNs）中的激活后的完全、分离和时间依赖性信号。本综述的目的是更新 HA 和 H3R 在纹状体功能的分子和信号水平上的作用。
