受影响的巨噬细胞亚群的特征及其对隐球菌病中发现的一种抑制性T细胞因子（TsFmp）的反应。
Characterization of the macrophage subset affected and its response to a T suppressor factor (TsFmp) found in cryptococcosis.
作者信息
Blackstock R, Hernandez N C
机构信息
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
出版信息
Infect Immun. 1989 Oct;57(10):2931-7. doi: 10.1128/iai.57.10.2931-2937.1989.
Previous reports from our laboratory described the detection of a suppressor factor which inhibited the phagocytic activity of a macrophage subset in murine cryptococcosis and in classical models of immune tolerance. The suppressor factor was originally named PIL (phagocytosis-inhibiting lymphokine) but has recently been renamed TsFmp (T suppressor factor for macrophage phagocytosis) because it was found to resemble the antigen-specific I-J-restricted suppressor factors described by others. The current investigation revealed that TsFmp acted rapidly upon the macrophage (15 min or less) to exert its effect of inhibiting the phagocytic process. The time for the macrophage to recover from the effects of TsFmp was likewise very rapid. The ability of TsFmp to inhibit phagocytosis was limited to engulfment of particles by Fc and mannan receptors and did not extent to phagocytosis via complement receptors or by nonspecific mechanisms. The macrophage subset that responded to TsFmp was determined to be in the I-A+ and I-J-IM+ subset.
我们实验室之前的报告描述了一种抑制因子的检测，该抑制因子在小鼠隐球菌病和经典免疫耐受模型中抑制巨噬细胞亚群的吞噬活性。该抑制因子最初被命名为PIL（吞噬抑制性淋巴因子），但最近被重新命名为TsFmp（巨噬细胞吞噬作用的T抑制因子），因为发现它类似于其他人描述的抗原特异性I-J限制抑制因子。目前的研究表明，TsFmp对巨噬细胞作用迅速（15分钟或更短时间）以发挥其抑制吞噬过程的作用。巨噬细胞从TsFmp的作用中恢复的时间同样非常迅速。TsFmp抑制吞噬作用的能力仅限于通过Fc和甘露聚糖受体吞噬颗粒，并不扩展到通过补体受体或非特异性机制的吞噬作用。对TsFmp有反应的巨噬细胞亚群被确定为I-A+和I-J-IM+亚群。
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