Morgan M A, Blackstock R A, Bulmer G S, Hall N K
Infect Immun. 1983 May;40(2):493-500. doi: 10.1128/iai.40.2.493-500.1983.
Normal C57BL/6J peritoneal cells exhibited a decreased phagocytosis when cultured with a cell wall antigen of Cryptococcus sp. and lymphocytes from mice infected with C. neoformans. Direct cell-to-cell interaction was not required in that supernatant fluids from cultures of lymphocytes from infected animals could be incubated with normal macrophage monolayers to give comparable suppression. The induction of the suppressor factor required specific cryptococcal antigen; however, suppression at the macrophage level was nonspecific in that the phagocytosis of C. neoformans and Saccharomyces cerevisiae were both decreased. Suppression appeared with lymphocyte supernatants taken from mice infected for 14 days and thereafter. The factor was heat stable, trypsin sensitive, and allospecific.
正常的C57BL/6J腹膜细胞在与隐球菌属的细胞壁抗原以及感染新型隐球菌的小鼠淋巴细胞共同培养时，吞噬作用会降低。不需要细胞间的直接相互作用，因为感染动物淋巴细胞培养物的上清液可以与正常巨噬细胞单层一起孵育，以产生类似的抑制作用。抑制因子的诱导需要特定的隐球菌抗原；然而，巨噬细胞水平的抑制是非特异性的，因为新型隐球菌和酿酒酵母的吞噬作用都降低了。从感染14天及以后的小鼠中获取的淋巴细胞上清液出现了抑制作用。该因子对热稳定，对胰蛋白酶敏感，且具有同种特异性。
