Marsh Pamela Jane, Polito Vince, Singh Subba, Coltheart Max, Langdon Robyn, Harris Anthony W
ARC Centre of Excellence in Cognition and its Disorders (CCD), Macquarie University, Sydney, NSW, 2109, Australia.
Rehabilitation Services, Cumberland Hospital, Westmead, NSW, Australia.
BMC Psychiatry. 2016 Oct 24;16(1):360. doi: 10.1186/s12888-016-1064-6.
Impaired ability to make inferences about what another person might think or feel (i.e., social cognition impairment) is recognised as a core feature of schizophrenia and a key determinant of the poor social functioning that characterizes this illness. The development of treatments to target social cognitive impairments as a causal factor of impaired functioning in schizophrenia is of high priority. In this study, we investigated the acceptability, feasibility, and limited efficacy of 2 programs targeted at specific domains of social cognition in schizophrenia: "SoCog" Mental-State Reasoning Training (SoCog-MSRT) and "SoCog" Emotion Recognition Training (SoCog-ERT).
Thirty-one participants with schizophrenia or schizoaffective disorder were allocated to either SoCog-MSRT (n = 19) or SoCog-ERT (n = 12). Treatment comprised 12 twice-weekly sessions for 6 weeks. Participants underwent assessments of social cognition, neurocognition and symptoms at baseline, post-training and 3-months after completing training.
Attendance at training sessions was high with an average of 89.29 % attendance in the SoCog-MSRT groups and 85.42 % in the SoCog-ERT groups. Participants also reported the 2 programs as enjoyable and beneficial. Both SoCog-MSRT and SoCog-ERT groups showed increased scores on a false belief reasoning task and the Reading the Mind in the Eyes test. The SoCog-MSRT group also showed reduced personalising attributional biases in a small number of participants, while the SoCog-ERT group showed improved emotion recognition.
The results are promising and support the feasibility and acceptability of the 2 SoCog programs as well as limited efficacy to improve social cognitive abilities in schizophrenia. There is also some evidence that skills for the recognition of basic facial expressions need specific training.
Australian New Zealand Clinical Trials Registry ACTRN12613000978763 . Retrospectively registered 3/09/2013.
对他人可能的想法或感受进行推理的能力受损（即社会认知障碍）被认为是精神分裂症的核心特征，也是该疾病所特有的社会功能不良的关键决定因素。将针对社会认知障碍的治疗方法作为精神分裂症功能受损的因果因素来开发，具有高度的优先性。在本研究中，我们调查了针对精神分裂症社会认知特定领域的两个项目的可接受性、可行性和有限疗效：“社会认知”心理状态推理训练（SoCog-MSRT）和“社会认知”情绪识别训练（SoCog-ERT）。
31名患有精神分裂症或分裂情感性障碍的参与者被分配到SoCog-MSRT组（n = 19）或SoCog-ERT组（n = 12）。治疗包括每周两次，共12节课程，为期6周。参与者在基线、训练后和完成训练3个月后接受社会认知评估、神经认知评估和症状评估。
训练课程的出勤率很高，SoCog-MSRT组的平均出勤率为89.29%，SoCog-ERT组为85.42%。参与者还报告这两个项目有趣且有益。SoCog-MSRT组和SoCog-ERT组在错误信念推理任务和“读心术”测试中的得分均有所提高。SoCog-MSRT组在少数参与者中还表现出个性化归因偏差减少，而SoCog-ERT组的情绪识别能力有所改善。
结果很有前景，支持了这两个社会认知项目的可行性和可接受性，以及它们在改善精神分裂症社会认知能力方面的有限疗效。也有一些证据表明识别基本面部表情的技能需要特定训练。
澳大利亚和新西兰临床试验注册中心ACTRN12613000978763。2013年9月3日追溯注册。
