Kim Jun Woo, Park Sang Hoo, Kim Yoojin, Im Minji, Han Heon-Seok
Department of Pediatrics, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Ann Pediatr Endocrinol Metab. 2016 Sep;21(3):143-148. doi: 10.6065/apem.2016.21.3.143. Epub 2016 Sep 30.
The prevalence rates of metabolic syndrome (MetS) and percentile distribution of insulin resistance (IR) among Korean children and adolescents were investigated. The cutoff values of IR were calculated to identify high-risk MetS groups.
Data from 3,313 Korean subjects (1,756 boys and 1,557 girls, aged 10-18 years) were included from the Korean National Health and Nutrition Examination Survey conducted during 2007-2010. Three different sets of criteria for MetS were used. Indirect measures of IR were homeostasis model assessment (HOMA-IR) and triglyceride and glucose (TyG) index. The cutoff values of the HOMA-IR and TyG index were obtained from the receiver operation characteristic curves.
According to the MetS criteria of de Ferranti el al., Cook et al., and the International Diabetes Federation, the prevalence rates in males and females were 13.9% and 12.3%, 4.6% and 3.6%, and 1.4% and 1.8%, respectively. Uses these 3 criteria, the cutoff values of the HOMA-IR and TyG index were 2.94 and 8.41, 3.29 and 8.38, and 3.54 and 8.66, respectively. The cutoff values using each of the 3 criteria approximately corresponds to the 50th-75th, 75th, and 75th-90th percentiles of normal HOMA-IR and TyG index levels.
This study describes the prevalence rates of MetS in Korean children and adolescents, an index of IR, and the cutoff values for MetS with the aim of detecting high-risk groups. The usefulness of these criteria needs to be verified by further evaluation.
调查韩国儿童和青少年中代谢综合征（MetS）的患病率以及胰岛素抵抗（IR）的百分位数分布。计算IR的临界值以识别高危MetS组。
纳入了2007 - 2010年期间进行的韩国国家健康与营养检查调查中的3313名韩国受试者（1756名男孩和1557名女孩，年龄10 - 18岁）。使用了三套不同的MetS标准。IR的间接测量指标为稳态模型评估（HOMA - IR）和甘油三酯与葡萄糖（TyG）指数。HOMA - IR和TyG指数的临界值从受试者工作特征曲线中获得。
根据de Ferranti等人、Cook等人以及国际糖尿病联盟的MetS标准，男性和女性的患病率分别为13.9%和12.3%、4.6%和3.6%、1.4%和1.8%。使用这3套标准时，HOMA - IR和TyG指数的临界值分别为2.94和8.41、3.29和8.38、3.54和8.66。使用这3套标准中的每一套得出的临界值大致分别对应正常HOMA - IR和TyG指数水平的第50 - 75百分位数、第75百分位数以及第75 - 90百分位数。
本研究描述了韩国儿童和青少年中MetS的患病率、IR指数以及用于检测高危组的MetS临界值。这些标准的实用性需要通过进一步评估来验证。
