Akcaboy Meltem, Melek Oguz Melahat, Altınel Acoglu Esma, Acar Mehtap, Zorlu Pelin, Ozbay Hosnut Ferda, Senel Saliha
Department of Pediatrics, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Department of Pediatric Gastroenterology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Iran Red Crescent Med J. 2016 Jun 14;18(8):e35086. doi: 10.5812/ircmj35086. eCollection 2016 Aug.
Rotavirus is a leading cause of acute gastroenteritis in children. Although the clinical complaints associated with rotavirus are generally gastrointestinal, including vomiting and diarrhea, data suggest that it can also cause symptoms that extend beyond the gastrointestinal tract.
We report three pediatric cases of rotavirus infection: one accompanied by encephalopathy and two with elevated hepatic transaminase activity. The patients were admitted to Dr. Sami Ulus maternity and children's health and diseases training and research hospital, Ankara, Turkey, from 2012 - 2014. The presented patients' aspartate aminotransferase (AST) (1765-2614 IU L) and alanine aminotransferase (ALT) (1448-3558 IU L) levels are, to date, the highest reported levels associated with rotavirus infections, and suggest that the rotavirus can cause severe hepatic transaminase elevation.
This report aimed to increase awareness of the occurrence of extra-intestinal systemic manifestations of rotavirus infection. Although such cases may be rare, they still suggest that that rotavirus is a systemic viral infection.
轮状病毒是儿童急性胃肠炎的主要病因。尽管与轮状病毒相关的临床症状通常为胃肠道症状，包括呕吐和腹泻，但数据表明它也可引发超出胃肠道范围的症状。
我们报告了3例轮状病毒感染的儿科病例：1例伴有脑病，2例肝转氨酶活性升高。这些患者于2012年至2014年期间被收治于土耳其安卡拉的萨米·乌卢斯妇幼保健与疾病培训和研究医院。目前所报告患者的天冬氨酸转氨酶（AST）（1765 - 2614 IU/L）和丙氨酸转氨酶（ALT）（1448 - 3558 IU/L）水平是迄今为止与轮状病毒感染相关的最高报告水平，这表明轮状病毒可导致严重的肝转氨酶升高。
本报告旨在提高对轮状病毒感染肠外系统表现发生情况的认识。尽管此类病例可能罕见，但仍表明轮状病毒是一种全身性病毒感染。
