Leonard M B, Vreman H J, Ferguson J E, Smith D W, Stevenson D K
Department of Pediatrics, Stanford University School of Medicine, California 94305.
J Dev Physiol. 1989 Feb;11(2):73-6.
We calculated the fetal-to-maternal carboxyhaemoglobin concentration ratio in 19 mother-infant pairs at the time of term delivery. Mothers, who had a less than 10% drop in their carboxyhaemoglobin concentration during labour, had an average ratio of 1.40 +/- 0.19. For mothers whose carboxyhaemoglobin concentrations dropped by 10% or more during labour, the average fetal-to-maternal carboxyhaemoglobin concentration ratio was 1.83 +/- 0.48. There was a strong correlation (r = 0.82) between the percent change in maternal carboxyhaemoglobin concentration during labour and the fetal-to-maternal carboxyhaemoglobin concentration ratio at the time of delivery. We conclude that increased CO elimination during labour may be accompanied by rapid changes in the maternal carboxyhaemoglobin concentration, leading to a spuriously high fetal-to-maternal carboxyhemoglobin concentration ratio at the time of delivery.
我们在足月分娩时计算了19对母婴的胎儿与母体碳氧血红蛋白浓度比。在分娩过程中碳氧血红蛋白浓度下降不到10%的母亲，其平均比值为1.40±0.19。对于在分娩过程中碳氧血红蛋白浓度下降10%或更多的母亲，胎儿与母体碳氧血红蛋白浓度的平均比值为1.83±0.48。分娩过程中母体碳氧血红蛋白浓度的变化百分比与分娩时胎儿与母体碳氧血红蛋白浓度比之间存在很强的相关性（r = 0.82）。我们得出结论，分娩过程中CO清除增加可能伴随着母体碳氧血红蛋白浓度的快速变化，导致分娩时胎儿与母体碳氧血红蛋白浓度比出现假性升高。
