Tuna Musaffe, Amos Christopher I
Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon.
Oncotarget. 2017 Jan 31;8(5):8877-8889. doi: 10.18632/oncotarget.12830.
Approximately 18% of all human cancers have a viral etiology, and human papillomavirus (HPV) has been identified as one of the most prevalent viruses that plays causative role in nearly all cervical cancers and, in addition, in subset of head and neck, anal, penile and vulvar cancers. The recent introduction of next generation sequencing (NGS) and other 'omics' approaches have resulted in comprehensive knowledge on the pathogenesis of HPV-driven tumors. Specifically, these approaches have provided detailed information on genomic HPV integration sites, disrupted genes and pathways, and common and distinct genetic and epigenetic alterations in different human HPV-associated cancers. This review focuses on HPV integration sites, its concomitantly disrupted genes and pathways and its functional consequences in both cervical and head and neck cancers. Integration of NGS data with other 'omics' and clinical data is crucial to better understand the pathophysiology of each individual malignancy and, based on this, to select targets and to design effective personalized treatment options.
约18%的人类癌症具有病毒病因，人乳头瘤病毒（HPV）已被确认为最常见的病毒之一，它在几乎所有宫颈癌以及部分头颈癌、肛门癌、阴茎癌和外阴癌中发挥致病作用。新一代测序（NGS）和其他“组学”方法的近期应用，使人们对HPV驱动肿瘤的发病机制有了全面认识。具体而言，这些方法提供了关于基因组HPV整合位点、受干扰的基因和通路，以及不同人类HPV相关癌症中常见和独特的基因及表观遗传改变的详细信息。本综述聚焦于HPV整合位点、其伴随的受干扰基因和通路，以及其在宫颈癌和头颈癌中的功能后果。将NGS数据与其他“组学”和临床数据整合起来，对于更好地理解每种恶性肿瘤的病理生理学，并据此选择靶点和设计有效的个性化治疗方案至关重要。
