金纳米棱锥-纳米棒对决：比较加热效率、细胞内化和热消融能力。
Gold nanoprism-nanorod face off: comparing the heating efficiency, cellular internalization and thermoablation capacity.
机构信息
Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film & Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 200240-Shanghai, PR China.
Instituto de Ciencia de Materiales de Aragón (ICMA-CSIC), Universidad de Zaragoza, 50009-Zaragoza, Spain.
出版信息
Nanomedicine (Lond). 2016 Nov;11(22):2903-2916. doi: 10.2217/nnm-2016-0257. Epub 2016 Oct 27.
AIM
This work compares the synthesis, heating capability, cellular internalization and thermoablation capacity of two different types of anisotropic gold nanoparticles: gold nanorods (NRs) and nanoprisms (NPrs).
METHODS
Both particles possess surface plasmon resonance absorption bands in the near-IR, and their heating efficiency upon irradiation with a continuous near-IR laser (1064 nm) was evaluated. The cellular internalization, location and toxicity of these PEG-stabilized NPrs and NRs were then assessed in the Vero cell line by transmission electron microscopy and inductively coupled plasma mass spectrometry analysis, and their ability to induce cell death upon laser irradiation was then evaluated and compared.
RESULTS & CONCLUSION: Although both nanoparticles are highly efficient photothermal converters, NRs possessed a more efficient heating capability, yet the in vitro thermoablation studies clearly demonstrated that NPrs were more effective at inducing cell death through photothermal ablation due to their greater cellular internalization.
目的
本工作比较了两种各向异性金纳米粒子——金纳米棒（NRs）和纳米棱柱（NPrs）的合成、加热能力、细胞内化和热消融能力。
方法
两种粒子均在近红外区具有表面等离子体共振吸收带，并用连续近红外激光（1064nm）照射来评估其加热效率。然后，通过透射电子显微镜和电感耦合等离子体质谱分析评估这些聚乙二醇稳定的 NPr 和 NR 在vero 细胞系中的细胞内化、位置和毒性，并评估和比较它们在激光照射下诱导细胞死亡的能力。
结果与结论
虽然两种纳米粒子都是高效的光热转换器，但 NRs 具有更高的加热能力，然而，体外热消融研究清楚地表明，由于 NPrs 具有更高的细胞内化能力，因此通过光热消融诱导细胞死亡的效果更好。
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