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西班牙的纳米医学研发：从纳米尺度改善疾病治疗

Nanomedical research and development in Spain: improving the treatment of diseases from the nanoscale.

作者信息

Fernández-Gómez Paula, Pérez de la Lastra Aranda Carmen, Tosat-Bitrián Carlota, Bueso de Barrio Jesús Alejandro, Thompson Sebastián, Sot Begoña, Salas Gorka, Somoza Álvaro, Espinosa Ana, Castellanos Milagros, Palomo Valle

机构信息

Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia), Madrid, Spain.

Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Spain.

出版信息

Front Bioeng Biotechnol. 2023 Jul 21;11:1191327. doi: 10.3389/fbioe.2023.1191327. eCollection 2023.

DOI:10.3389/fbioe.2023.1191327
PMID:37545884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10401050/
Abstract

The new and unique possibilities that nanomaterials offer have greatly impacted biomedicine, from the treatment and diagnosis of diseases, to the specific and optimized delivery of therapeutic agents. Technological advances in the synthesis, characterization, standardization, and therapeutic performance of nanoparticles have enabled the approval of several nanomedicines and novel applications. Discoveries continue to rise exponentially in all disease areas, from cancer to neurodegenerative diseases. In Spain, there is a substantial net of researchers involved in the development of nanodiagnostics and nanomedicines. In this review, we summarize the state of the art of nanotechnology, focusing on nanoparticles, for the treatment of diseases in Spain (2017-2022), and give a perspective on the future trends and direction that nanomedicine research is taking.

摘要

纳米材料所提供的全新且独特的可能性已对生物医学产生了巨大影响，从疾病的治疗与诊断到治疗药物的特异性及优化递送。纳米颗粒在合成、表征、标准化及治疗性能方面的技术进步已促成了多种纳米药物的获批及新应用。从癌症到神经退行性疾病，所有疾病领域的相关发现都在呈指数级增长。在西班牙，有一大批研究人员参与到纳米诊断和纳米药物的研发中。在本综述中，我们总结了西班牙（2017 - 2022年）用于疾病治疗的纳米技术（重点是纳米颗粒）的现状，并对纳米医学研究的未来趋势和方向进行了展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/6b10388bd323/fbioe-11-1191327-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/658759964391/fbioe-11-1191327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/26bec5be181c/fbioe-11-1191327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/3e0ffd469a9c/fbioe-11-1191327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/ec83a1d8b42f/fbioe-11-1191327-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/ed64020d0cde/fbioe-11-1191327-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/a7c9a8ff56cc/fbioe-11-1191327-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/6b10388bd323/fbioe-11-1191327-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/658759964391/fbioe-11-1191327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/26bec5be181c/fbioe-11-1191327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/3e0ffd469a9c/fbioe-11-1191327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/ec83a1d8b42f/fbioe-11-1191327-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/ed64020d0cde/fbioe-11-1191327-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/a7c9a8ff56cc/fbioe-11-1191327-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b5c/10401050/6b10388bd323/fbioe-11-1191327-g007.jpg

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本文引用的文献

[1]
3D spatial organization and improved antibiotic treatment of a wound biofilm by nanoparticle enzyme delivery.

Front Microbiol. 2022-11-16

[2]
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ACS Nano. 2022-11-22

[3]
Bioevaluation of magnetic mesoporous silica rods: cytotoxicity, cell uptake and biodistribution in zebrafish and rodents.

RSC Adv. 2022-11-7

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Antibiotic delivery from bone-targeted mesoporous silica nanoparticles for the treatment of osteomyelitis caused by methicillin-resistant Staphylococcus aureus.

Acta Biomater. 2022-12

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Optomagnetic nanofluids for controlled brain hyperthermia: a critical study.

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Silver Nanoparticles Produced by Laser Ablation and Re-Irradiation Are Effective Preventing Peri-Implantitis Multispecies Biofilm Formation.

Int J Mol Sci. 2022-10-10

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Nanoscale Adv. 2021-9-28

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A Promising Antifungal and Antiamoebic Effect of Silver Nanorings, a Novel Type of AgNP.

Antibiotics (Basel). 2022-8-3

[10]
Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity.

Int J Mol Sci. 2022-8-5

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