Buchanan R R, Wardlaw J R, Riglar A G, Littlejohn G O, Miller M H
Department of Medicine, Austin Hospital, Melbourne, Australia.
J Rheumatol. 1989 Jun;16(6):757-61.
Anticardiolipin antibodies (aCL) were measured in the sera of patients with different connective tissue diseases and spondyloarthropathies. Elevated antibody binding was found in systemic lupus erythematosus (SLE), rheumatoid arthritis, scleroderma, primary sicca syndrome, dermatopolymyositis and psoriatic arthritis but not in ankylosing spondylitis. The 15 highest binding SLE patients included 10 with Raynaud's phenomenon, 5 with livedo reticularis, 7 with vasculitis, 3 with major thrombotic episodes and 3 with spontaneous abortions. aCL were also measured in patients with these clinical features in isolation. Seven of 18 patients with multiple thromboses and 3/22 with multiple spontaneous abortions had raised aCL binding. Normal or near normal levels were found in patients with idiopathic thrombocytopenia, livedo reticularis, a single cerebral thrombosis and uncomplicated myocardial infarction.
在患有不同结缔组织病和脊柱关节病的患者血清中检测抗心磷脂抗体（aCL）。在系统性红斑狼疮（SLE）、类风湿关节炎、硬皮病、原发性干燥综合征、皮肌炎和银屑病关节炎患者中发现抗体结合升高，但强直性脊柱炎患者中未发现。15例抗体结合水平最高的SLE患者中，10例有雷诺现象，5例有网状青斑，7例有血管炎，3例有严重血栓形成发作，3例有自然流产。还对仅具有这些临床特征的患者进行了aCL检测。18例多发性血栓形成患者中有7例，22例多次自然流产患者中有3例aCL结合升高。特发性血小板减少症、网状青斑、单发脑血栓形成和无并发症心肌梗死患者的aCL水平正常或接近正常。
