Hrncír Z, Chýlková V
2. interní klinika lékarské fakulty Univerzity Karlovy, Hradec Králové.
Vnitr Lek. 1990 Nov;36(11):1041-9.
Anticardiolipin (aCL) antibodies were assessed in isotypes IgG, IgM and IgA by the enzyme immunochemical technique in serum of 86 subjects with diffuse connective tissue affections and in 75 subjects of three control groups (syphilis, syndrome of common variable immunodeficiency and blood donors). In systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and syphilis the mean values of the three isotypes of aCL antibodies were significantly higher than in blood donors (p = 0.05 to 0.001); in diffuse scleroderma and primary polymyositis/dermatomyositis in isotype IgG (p = 0.01-0.001). Positive findings of aCL antibodies (isolated or in combinations of Ig isotypes (were found most frequently in SLE (34.4%), RA (33.3%) and syphilis (66.6%); sera of blood donors were positive in 8.7%. Venous thrombosis was recorded in the case-records of 28% patients with SLE but only in 5.4% of those with RA. Spontaneous abortion terminated 8/66 pregnancies in 28 women with SLE. In one female patient with SLE the aCL syndrome was detected. On account of frequent positivity of aCL antibodies in syphilis, the authors consider it essential to rule out the coincidence of this disease. Examination of aCL-IgA antibodies extends the detection of positive cases (isolated or in combinations of Ig) in SLE and RA.
采用酶免疫化学技术，对86例弥漫性结缔组织病患者及三个对照组（梅毒、常见可变免疫缺陷综合征患者及献血者）的75例受试者血清中的抗心磷脂（aCL）抗体IgG、IgM和IgA三种亚型进行了检测。在系统性红斑狼疮（SLE）、类风湿关节炎（RA）和梅毒患者中，aCL抗体三种亚型的平均值显著高于献血者（p = 0.05至0.001）；在弥漫性硬皮病和原发性多发性肌炎/皮肌炎患者中，IgG亚型的aCL抗体平均值也显著高于献血者（p = 0.01 - 0.001）。aCL抗体阳性结果（单独或Ig亚型组合阳性）最常见于SLE（34.4%）、RA（33.3%）和梅毒（66.6%）患者；献血者血清阳性率为8.7%。在SLE患者的病历记录中，28%的患者有静脉血栓形成，而RA患者中仅有5.4%有静脉血栓形成。28例SLE女性患者中有8/66次妊娠发生自然流产。1例SLE女性患者检测出aCL综合征。鉴于梅毒患者中aCL抗体常呈阳性，作者认为必须排除该病的合并存在。检测aCL - IgA抗体可增加SLE和RA患者中阳性病例（单独或Ig组合阳性）的检出率。
