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转运蛋白18 kDa（TSPO）配体对小胶质细胞和星形胶质细胞中Toll样受体介导的促炎反应的系统分析

Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes.

作者信息

Lee Ji-Won, Nam Hyeri, Yu Seong-Woon

机构信息

Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.

Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.; Neurometabolomics Research Center, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.

出版信息

Exp Neurobiol. 2016 Oct;25(5):262-268. doi: 10.5607/en.2016.25.5.262. Epub 2016 Oct 18.

DOI:10.5607/en.2016.25.5.262
PMID:27790060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5081472/
Abstract

Translocator protein 18 kDa (TSPO) is a mitochondrial protein highly expressed on reactive microglia and astrocytes, and is considered as a biomarker for neurodegeneration and brain damage, especially neuroinflammation. Toll-like receptors (TLRs) are closely related with inflammatory responses of microglia and astrocytes and these signaling pathways regulate neuroinflammation. Previous reports have identified the anti-inflammatory effects of TSPO ligands, however study of their effects in relation to the TLR signaling was limited. Here, we investigated the effects of five representative TSPO ligands on microglia and astrocytes following activation by various TLR ligands. Our results show that TSPO ligands reduce the pro-inflammatory response elicited by the TLR ligands with more profound effects on microglia than astrocytes.

摘要

18 kDa转运蛋白（TSPO）是一种在线粒体上高度表达的蛋白质，在反应性小胶质细胞和星形胶质细胞上也有高表达，被认为是神经退行性变和脑损伤，尤其是神经炎症的生物标志物。Toll样受体（TLR）与小胶质细胞和星形胶质细胞的炎症反应密切相关，这些信号通路调节神经炎症。先前的报道已证实TSPO配体具有抗炎作用，然而，关于它们与TLR信号传导相关作用的研究却很有限。在此，我们研究了五种代表性TSPO配体对各种TLR配体激活后的小胶质细胞和星形胶质细胞的影响。我们的结果表明，TSPO配体可降低TLR配体引发的促炎反应，对小胶质细胞的影响比对星形胶质细胞的影响更为显著。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/6c48cd7f250d/en-25-262-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/0e4d9e65051b/en-25-262-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/0c192b2f026d/en-25-262-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/02f6e0c60a56/en-25-262-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/6fe7fa26fb5c/en-25-262-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/6c48cd7f250d/en-25-262-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/0e4d9e65051b/en-25-262-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/0c192b2f026d/en-25-262-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/02f6e0c60a56/en-25-262-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/6fe7fa26fb5c/en-25-262-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bb/5081472/6c48cd7f250d/en-25-262-g005.jpg

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2
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Sci Rep. 2016 Mar 1;6:22556. doi: 10.1038/srep22556.
3
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Exp Neurobiol. 2023 Aug 31;32(4):259-270. doi: 10.5607/en23012.
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Brain Behav Immun Health. 2022 Nov 8;26:100554. doi: 10.1016/j.bbih.2022.100554. eCollection 2022 Dec.
5
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6
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4
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5
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6
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7
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J Neuroimmune Pharmacol. 2014 Jun;9(3):424-37. doi: 10.1007/s11481-014-9540-6. Epub 2014 Apr 1.
8
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10
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