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肺腺癌双侧脉络膜转移:一例报告

Bilateral Choroidal Metastases from Lung Adenocarcinoma: A Case Report.

作者信息

Ergenc Hasan, Onmez Attila, Oymak Ezgi, Tanriseven Ramiser, Celik Erkan, Onmez Funda Ebru, Tamer Ali, Baykara Meltem

机构信息

Sakarya University Training and Research Hospital, Department of Internal Medicine, Sakarya, Turkey.

Turkey Republic Ministry of Health Kocaali State Hospital, Department of Internal Medicine, Sakarya, Turkey.

出版信息

Case Rep Oncol. 2016 Sep 13;9(3):530-536. doi: 10.1159/000449154. eCollection 2016 Sep-Dec.

DOI:10.1159/000449154
PMID:27790116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5073677/
Abstract

The most common malignancy of the eye is metastatic tumors, with choroidal metastases being the majority of them. In women, breast cancer is the most common cause of orbital metastases, and in men, it is lung cancer. Despite the fact that there are efficient treatment options for orbital metastases, the benefit of procedures to detect choroidal metastases is debatable due to the quick progression and poor prognosis of lung cancer. In choroidal metastases resulting from lung cancer, patients are usually presented with decreased sight. Defects in the field of vision, flashes of light and floating bodies generally follow. Treatment options of choroidal metastases include many methods including laser photocoagulation, cryotherapy, chemotherapy, radiotherapy, surgical resection, enucleation and photodynamic therapy. There are reports emphasizing radiotherapy as the most efficient treatment option. In this case report, we sum up the case of a male patient presenting with blurry vision in both eyes, who was subsequently detected to have bilateral choroidal metastatic tumor and was diagnosed with primary lung adenocarcinoma.

摘要

眼部最常见的恶性肿瘤是转移性肿瘤,其中大多数为脉络膜转移瘤。在女性中,乳腺癌是眼眶转移最常见的原因,而在男性中则是肺癌。尽管有针对眼眶转移的有效治疗方案,但由于肺癌进展迅速且预后不良,检测脉络膜转移瘤的程序的益处仍存在争议。在由肺癌引起的脉络膜转移中,患者通常会出现视力下降。随后通常会出现视野缺损、闪光和飞蚊症。脉络膜转移瘤的治疗选择包括多种方法,如激光光凝、冷冻疗法、化疗、放疗、手术切除、眼球摘除和光动力疗法。有报告强调放疗是最有效的治疗选择。在本病例报告中,我们总结了一名双眼视力模糊的男性患者的病例,该患者随后被检测出患有双侧脉络膜转移瘤,并被诊断为原发性肺腺癌。

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Choroidal metastasis as a presenting feature in a metastatic lung carcinoma.

本文引用的文献

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Combination of intravitreal bevacizumab and systemic therapy for choroidal metastases from lung cancer: report of two cases and a systematic review of literature.玻璃体内注射贝伐单抗联合全身治疗肺癌脉络膜转移:两例报告及文献系统综述
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Photodynamic therapy for choroidal metastasis from lung adenocarcinoma.光动力疗法治疗肺腺癌脉络膜转移
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脉络膜转移作为转移性肺癌的首发特征。
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Uveal metastasis from breast cancer in 264 patients.264例乳腺癌患者的葡萄膜转移
Am J Ophthalmol. 2003 Aug;136(2):264-71. doi: 10.1016/s0002-9394(03)00192-2.
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Choroidal metastasis in disseminated lung cancer: frequency and risk factors.播散性肺癌中的脉络膜转移:发生率及危险因素
Am J Ophthalmol. 2002 Sep;134(3):445-7. doi: 10.1016/s0002-9394(02)01580-5.
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Survey of 520 eyes with uveal metastases.520例葡萄膜转移瘤患者的调查。
Ophthalmology. 1997 Aug;104(8):1265-76. doi: 10.1016/s0161-6420(97)30148-1.
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Functional vision is improved in the majority of patients treated with external-beam radiotherapy for choroid metastases: a multivariate analysis of 188 patients.
J Clin Oncol. 1997 Mar;15(3):1244-51. doi: 10.1200/JCO.1997.15.3.1244.
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Tumors metastatic to the orbit: a changing picture.转移至眼眶的肿瘤:不断变化的情况。
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