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[缺血性心脏病患者家族中的血脂与脂质过氧化物]

[Blood lipids and lipid peroxides in the families of patients with ischemic heart disease].

作者信息

Davidenkova E F, Shafran M G, Veksler B M, Magracheva E Ia, Lozovskiĭ V T

出版信息

Kardiologiia. 1989 Jun;29(6):10-4.

PMID:2779063
Abstract

Levels of some fractions of blood neutral lipids and lipoperoxides were compared in the families of patients with coronary heart disease. The patients and their relatives (including healthy ones) were found to show a statistically significant increase in the atherogenic index, total cholesterol, low density lipoprotein cholesterol, triglyceride, total lipid, and lipoperoxide concentrations and a decrease in high density lipoprotein cholesterol levels as against controls. The changes in the values of lipids and lipoperoxides in the families of patients with coronary heart disease were homogenous and might be one of the pathogenetic links in the formation of hereditary predisposition to atherosclerotic cardiovascular diseases which might be detected in a prehospital period.

摘要

对冠心病患者家庭中血液中性脂质和脂质过氧化物的某些组分水平进行了比较。发现患者及其亲属(包括健康亲属)与对照组相比,动脉粥样硬化指数、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、总脂质和脂质过氧化物浓度在统计学上有显著升高,而高密度脂蛋白胆固醇水平降低。冠心病患者家庭中脂质和脂质过氧化物值的变化是一致的,可能是动脉粥样硬化性心血管疾病遗传易感性形成的发病机制环节之一,这种遗传易感性可能在院前阶段被检测到。

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