Chernyshov V A, Tseluĭko V I
Kardiologiia. 1992 Mar;32(3):13-7.
The paper presents a clinical and genealogical characterization of 50 probands suffering from coronary heart disease concurrent with various lipid metabolic disturbances and 211 first-degree relatives whose data have been obtained from the probands' histories while making up their pedigrees. The prevalence of atherosclerosis among the first-degree relatives has been demonstrated to be related to the nature of lipid metabolic disturbances in a proband. Some dyslipoproteinemias in the proband have been characterized by early onset of coronary heart disease, stroke, and their grave course in close relatives.
本文介绍了50例患有冠心病并伴有各种脂质代谢紊乱的先证者以及211名一级亲属的临床和系谱特征,这些一级亲属的数据是在构建系谱时从先证者病史中获取的。已证明一级亲属中动脉粥样硬化的患病率与先证者脂质代谢紊乱的性质有关。先证者中的一些血脂蛋白异常表现为冠心病和中风发病早,且在近亲中病情严重。