Prudnikova L Z, Alekberova Z S, Nasonov E L, Side'lnikova V M, Manuĭlova L P
Klin Med (Mosk). 1989 Jun;67(6):59-64.
Examination of 115 women for detection of phospholipid antibodies (PLA), lupus anticoagulant and cardiolipin antibodies has demonstrated that in the absence of PLA all pregnancies terminated in the birth of full-term healthy children, while in their presence there were repeated abortions and (or) intrauterine death of a fetus. Obstetrical pathology in women in the presence of PLA was attended by venous and arterial thrombosis, thrombocytopenia, cerebral vasculitis and vascular affections, which is typical of the picture of the antiphospholipid syndrome. A new approach has been suggested to the treatment of such patients with reduction of the activity of lupus anticoagulant and cardiolipin antibodies owing to which pregnancy can be terminated in the birth of viable children.
对115名女性进行磷脂抗体（PLA）、狼疮抗凝物和心磷脂抗体检测，结果表明，在没有PLA的情况下，所有妊娠均以足月健康婴儿出生告终，而在有PLA的情况下，则出现反复流产和（或）胎儿宫内死亡。存在PLA的女性产科病理伴有静脉和动脉血栓形成、血小板减少、脑血管炎和血管病变，这是抗磷脂综合征的典型表现。已提出一种新的治疗此类患者的方法，可降低狼疮抗凝物和心磷脂抗体的活性，从而使妊娠能够以存活婴儿出生告终。
