通过桑德迈尔型反应实现无金属芳香碳-磷键形成。
Metal-Free Aromatic Carbon-Phosphorus Bond Formation via a Sandmeyer-Type Reaction.
机构信息
Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University , Beijing 100871, China.
出版信息
J Org Chem. 2016 Dec 2;81(23):11603-11611. doi: 10.1021/acs.joc.6b01820. Epub 2016 Nov 7.
An efficient metal-free phosphorylation process based on a Sandmeyer-type transformation with arylamines as the starting materials is developed. The transformation proceeds smoothly at room temperature without the exclusion of moisture or air. This phosphorylation reaction tolerates a wide range of functional groups and affords the phosphorylation products in moderate to good yields, thus providing a valuable method for the formation of aromatic carbon-phosphorus bonds.
发展了一种基于桑德迈尔型转化的高效无金属磷酸化方法，以芳胺作为起始原料。该转化在室温下顺利进行，无需排除水分或空气。这种磷酸化反应对多种官能团具有耐受性，并以中等至良好的收率得到磷酸化产物，因此为形成芳基碳-磷键提供了一种有价值的方法。
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