Lahimer Marwa, Capelle Severine, Lefranc Elodie, Bosquet Dorian, Kazdar Nadia, Ledu Anne, Agina Mounir, Cabry Rosalie, BenKhalifa Moncef
ART and Reproductive Biology Laboratory, University Hospital and School of Medicine, Picardie University Jules Verne, CHU Sud, 80000 Amiens, France.
PERITOX-(UMR-I 01), UPJV/INERIS, UPJV, CURS, Chemin du Thil, 80025 Amiens, France.
Nutrients. 2025 Jan 17;17(2):324. doi: 10.3390/nu17020324.
Today, accumulating evidence highlights the impact of oxidative stress (OS) on semen quality. It is considered to be a key factor contributing to the decline in male fertility. OS is detected in 30-80% of men with infertility, highlighting its strong association with impaired reproductive function and with clinical outcomes following the use of assisted reproductive technologies. Spermatozoa are particularly vulnerable to oxidative damage due to their high content of polyunsaturated fatty acids (PUFAs) and limited antioxidant defense abilities. OS arises from an imbalance between the production of reactive oxygen species and the capacity to neutralize or repair their adverse effects. Evidence indicates that OS leads to lipid peroxidation, protein oxidation, mitochondrial dysfunction, and genomic instability. Micronutrient-antioxidant therapies can play a key role in infertility improvement by neutralizing free radicals and preventing cellular damage. Many different micronutrients, including L-carnitine, L-glutathione, coenzyme Q10, selenium, and zinc, as well as vitamins complexes, are proposed to improve sperm parameters and male fertility potential. This study aims to review the impact of antioxidant supplementation on semen parameters, including sperm volume, motility, concentration, morphology, genome integrity (maturity and fragmentation), and in vitro fertilization (IVF) outcomes. Antioxidant intake and a balanced lifestyle reduce oxidative stress and mitochondrial dysfunction, enhancing the spermatogenesis and spermiogenesis processes, improving sperm quality, and protecting DNA integrity.
如今，越来越多的证据凸显了氧化应激（OS）对精液质量的影响。它被认为是导致男性生育能力下降的一个关键因素。在30%至80%的不育男性中可检测到氧化应激，这凸显了其与生殖功能受损以及辅助生殖技术应用后的临床结果之间的紧密关联。由于精子中多不饱和脂肪酸（PUFA）含量高且抗氧化防御能力有限，精子特别容易受到氧化损伤。氧化应激源于活性氧的产生与中和或修复其不利影响的能力之间的失衡。有证据表明，氧化应激会导致脂质过氧化、蛋白质氧化、线粒体功能障碍和基因组不稳定。微量营养素抗氧化疗法通过中和自由基和防止细胞损伤，在改善不育方面可发挥关键作用。许多不同的微量营养素，包括左旋肉碱、左旋谷胱甘肽、辅酶Q10、硒和锌，以及维生素复合物，都被认为可以改善精子参数和男性生育潜力。本研究旨在综述抗氧化剂补充对精液参数的影响，包括精液量、活力、浓度、形态、基因组完整性（成熟度和碎片率）以及体外受精（IVF）结果。摄入抗氧化剂和保持均衡的生活方式可减轻氧化应激和线粒体功能障碍，增强精子发生和精子形成过程，提高精子质量，并保护DNA完整性。
