The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, New York.
Fertil Steril. 2017 Jan;107(1):104-109.e2. doi: 10.1016/j.fertnstert.2016.09.044. Epub 2016 Oct 25.
To investigate the impact of prolonged ovarian stimulation on pregnancy outcomes in IVF cycles with fresh day 3 ET.
Retrospective cohort study.
University-affiliated center.
PATIENT(S): All patients initiating their first IVF cycle with fresh day 3 ET. Prolonged ovarian stimulation was defined as a duration of more than two standard deviations (95th percentile) for the study cohort (i.e., >13 days).
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Live birth rate was considered the primary outcome and was compared between patients undergoing ovarian stimulation for ≤13 days and >13 days. Odds ratios (OR) with 95% confidence intervals (CI) for all pregnancy outcomes after day 3 ET were calculated. The OR for live birth was adjusted using logistic regression.
RESULT(S): A total of 6,410 and 339 patients underwent ovarian stimulation for ≤13 days and >13 days, respectively. There were no differences in the demographics or mean number of day 3 embryos transferred between the two groups. Ovarian stimulation ≤13 days was associated with increased odds of clinical pregnancy (OR 2.15, 95% CI 1.19-3.89) and live birth (OR 2.35, 95% CI 1.25-4.43). The increased odds for live birth in the ≤13-day group remained unchanged after logistic regression. Patients with clinical pregnancies in the >13-day group were younger (34.6 ± 4.91 years) compared with those who did not conceive (38.2 ± 4.72 years).
CONCLUSION(S): Our findings suggest that ovarian stimulation ≤13 days is associated with increased odds of clinical pregnancy and live birth. In patients undergoing ovarian stimulation >13 days, younger age is associated with live birth.
研究新鲜胚胎移植日 3 天（ET）行体外受精（IVF）周期中，卵巢刺激时间延长对妊娠结局的影响。
回顾性队列研究。
大学附属医院。
所有首次新鲜胚胎移植日 3 天行 IVF 周期的患者。卵巢刺激时间延长定义为研究队列的持续时间超过两个标准差（95%百分位数）（即>13 天）。
无。
活产率被认为是主要结局，并在卵巢刺激时间≤13 天和>13 天的患者之间进行比较。计算第 3 天 ET 后所有妊娠结局的优势比（OR）及其 95%置信区间（CI）。使用逻辑回归对活产的 OR 进行调整。
共有 6410 例和 339 例患者的卵巢刺激时间分别≤13 天和>13 天。两组间的人口统计学资料或第 3 天胚胎移植的平均数量无差异。卵巢刺激时间≤13 天与临床妊娠（OR 2.15，95%CI 1.19-3.89）和活产（OR 2.35，95%CI 1.25-4.43）的优势比增加相关。≤13 天组中活产的优势比在逻辑回归后保持不变。在>13 天组中，有临床妊娠的患者年龄较小（34.6±4.91 岁），而未妊娠的患者年龄较大（38.2±4.72 岁）。
我们的研究结果表明，卵巢刺激时间≤13 天与临床妊娠和活产的优势比增加相关。在卵巢刺激时间>13 天的患者中，年轻与活产相关。
