阿拉伯半岛人种与接受新鲜 ICSI 周期的女性的卵巢储备和卵巢反应较低有关。
Arabian Peninsula ethnicity is associated with lower ovarian reserve and ovarian response in women undergoing fresh ICSI cycles.
机构信息
Weill Cornell Medicine-Qatar, Doha, Qatar.
The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Ave., New York, NY, 10021, USA.
出版信息
J Assist Reprod Genet. 2018 Feb;35(2):331-337. doi: 10.1007/s10815-017-1071-7. Epub 2017 Oct 23.
PURPOSE
Recent studies have demonstrated that ethnicity can be an independent determinant of assisted reproductive technology (ART) outcomes. In this context, we investigate whether ART outcomes differ between Arabian Peninsula and Caucasian women.
METHODS
This is a retrospective cohort study of women undergoing fresh intracytoplasmic sperm injection (ICSI)-embryo transfer (ET) cycles for male factor infertility. The study cohort was divided into 2 groups based on ethnicity-Arabian Peninsula or Caucasian. Ovarian reserve, ovarian response, and pregnancy outcomes were compared between the groups. A sub-analysis was performed between individual Arabian Peninsula nationalities for the same outcomes. A multiple linear regression model was used to assess the independent effect of ethnicity on ovarian response.
RESULTS
Seven hundred sixty-three patients were included-217 (28.4%) Arabian Peninsula and 546 (71.6%) Caucasian. There was no difference in the mean age of the two groups; however, the former had a higher body mass index (28.5 ± 7.5 vs. 23.3 ± 5.7; P < 0.001). Although follicle stimulating hormone (FSH) levels and antral follicle counts (AFC) were within the normal range in both groups, Arabian Peninsula women had higher FSH levels (5.7 ± 2.5 vs. 4.9 ± 2.8; P = 0.001) and lower AFC (13.9 ± 4.7 vs. 16.5 ± 4.3; P < 0.001) when compared to Caucasian women. Women from the Arabian Peninsula also had a statistically lower number of mature oocytes retrieved (15.6 ± 6.8 vs. 14.1 ± 8.4; P = 0.01), despite requiring higher gonadotropin doses. Multiple linear regression reveled that Arabian Peninsula women had 2.5 (95% CI 2.1-3.9) less mature oocytes, even after controlling for confounders. A sub-analysis within the Arab cohort demonstrated that Qatari women had a higher yield of mature oocytes when compared to Emirati, Kuwaiti, and Saudi women. There was no difference in the rates of implantation, clinical pregnancy, or live birth when comparing individual Arabian Peninsula nationalities with each other or to Caucasians.
CONCLUSIONS
Arabian Peninsula ethnicity is associated with lower ovarian reserve and ovarian response parameters in women undergoing their first ICSI-ET cycle.
目的
最近的研究表明，种族是辅助生殖技术（ART）结果的一个独立决定因素。在这种情况下，我们研究了阿拉伯半岛和高加索妇女的 ART 结果是否存在差异。
方法
这是一项回顾性队列研究，纳入了因男性因素不育接受新鲜胞浆内单精子注射（ICSI）-胚胎移植（ET）周期的妇女。根据种族（阿拉伯半岛或高加索）将研究队列分为两组。比较两组之间的卵巢储备、卵巢反应和妊娠结局。对同一结局的个别阿拉伯半岛国籍进行了亚分析。使用多元线性回归模型评估种族对卵巢反应的独立影响。
结果
共纳入 763 例患者-217 例（28.4%）为阿拉伯半岛人，546 例（71.6%）为高加索人。两组的平均年龄无差异；然而，前者的体重指数（BMI）较高（28.5±7.5 vs. 23.3±5.7；P<0.001）。尽管两组的卵泡刺激素（FSH）水平和窦卵泡计数（AFC）均在正常范围内，但阿拉伯半岛妇女的 FSH 水平较高（5.7±2.5 vs. 4.9±2.8；P=0.001），AFC 较低（13.9±4.7 vs. 16.5±4.3；P<0.001）。与高加索妇女相比，阿拉伯半岛妇女的成熟卵母细胞数也明显较少（15.6±6.8 vs. 14.1±8.4；P=0.01），尽管需要更高的促性腺激素剂量。多元线性回归显示，即使在控制混杂因素后，阿拉伯半岛妇女的成熟卵母细胞也少 2.5 个（95%CI 2.1-3.9）。阿拉伯队列内的亚分析表明，与阿联酋、科威特和沙特妇女相比，卡塔尔妇女的成熟卵母细胞产量更高。比较个别阿拉伯半岛国家之间以及与高加索人之间的胚胎着床率、临床妊娠率或活产率没有差异。
结论
在接受首次 ICSI-ET 周期的妇女中，阿拉伯半岛种族与较低的卵巢储备和卵巢反应参数相关。
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