自然种群中蛋白质的亚基分子量和遗传变异性
Subunit molecular weight and genetic variability of proteins in natural populations.
作者信息
Nei M, Fuerst P A, Chakraborty R
出版信息
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3359-62. doi: 10.1073/pnas.75.7.3359.
Abstract
The relationship between subunit molecular weight and heterozygosity was studied in six different groups of organisms, i.e., 9 species of primates, 32 species of rodents, 56 species of reptiles, 12 species of salamanders, 64 species of teleost fishes, and 29 species of Drosophila. The correlation coefficient between them was positive in all groups, and the magnitude of correlation was roughly in agreement with the theoretical expectation under the mutation-drift hypothesis when the incomplete correlation between molecular weight and mutation rate was taken into account. Furthermore, the correlation was higher when the average heterozygosity was high than when this was low, as theoretically expected.
摘要
在六组不同的生物体中研究了亚基分子量与杂合性之间的关系，这六组生物体分别是：9种灵长类动物、32种啮齿动物、56种爬行动物、12种蝾螈、64种硬骨鱼以及29种果蝇。在所有组中，它们之间的相关系数均为正值，并且当考虑到分子量与突变率之间的不完全相关性时，相关程度大致与突变 - 漂变假说下的理论预期相符。此外，正如理论预期的那样，平均杂合性高时的相关性高于平均杂合性低时的相关性。
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