Li W H
J Mol Evol. 1979 Apr 12;12(4):319-29. doi: 10.1007/BF01732027.
The effect of changes in population size on the correlation between mutation rate and heterozygosity was studied by using two models: sudden change in population size and gradual change. It was shown that the results for the two models are close to each other, unless the rate of change for the latter is exceedingly slow. Thus, in many cases, the former model, which is much simpler than the latter, can be used to treat the present problem. Numerical computations showed that the correlation in a population that is expanding or has expanded in the recent past is stronger while the correlation in a population that is decreasing or has experienced a population reduction or bottleneck in the recent past is weaker than that for an equilibrium population with the same mean heterozygosity. However, regardless of whether the population is at equilibrium or not, the proportion of variation in heterozygosity that is attributable to variation in molecular weight over loci is rather small if the mean heterozygosity of the population is low, say of the order 0.05 or smaller.
种群大小的突然变化和逐渐变化。结果表明，除非后者的变化率极其缓慢，否则两种模型的结果彼此接近。因此，在许多情况下，可以使用比后者简单得多的前一种模型来处理当前问题。数值计算表明，在最近正在扩张或已经扩张的种群中，相关性更强，而在最近正在减少或经历过种群数量减少或瓶颈的种群中，相关性比具有相同平均杂合度的平衡种群要弱。然而，无论种群是否处于平衡状态，如果种群的平均杂合度较低，比如在0.05或更小的量级，那么杂合度变化中可归因于位点间分子量变化的比例相当小。
