具有可变突变率的无限等位基因模型。
Infinite allele model with varying mutation rate.
作者信息
Nei M, Chakraborty R, Fuerst P A
出版信息
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4164-8. doi: 10.1073/pnas.73.11.4164.
Abstract
Available data suggest that the variation in mutation rate among protein loci follows the gamma distribution. Thus, taking into account this variation, formulae are developed for the distribution of allele frequencies, mean and variance of heterozygosity, expected number of alleles, proportion of polymorphic loci, and genetic distance. These formulae should be more appropriate for the analysis of gene frequency data for protein loci than equivalent formulae with constant mutation rate.
摘要
现有数据表明，蛋白质位点间突变率的变化遵循伽马分布。因此，考虑到这种变化，我们推导出了关于等位基因频率分布、杂合度均值和方差、等位基因期望数量、多态性位点比例以及遗传距离的公式。与具有恒定突变率的等效公式相比，这些公式应该更适合用于分析蛋白质位点的基因频率数据。
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