Tani Chikako, Pratakpiriya Watanyoo, Tani Mineto, Yamauchi Takenori, Hirai Takuya, Yamaguchi Ryoji, Ano Hitoshi, Katamoto Hiromu
Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, 5200, Kihara, Kiyotake, Miyazaki 889-1692, Japan.
J Vet Med Sci. 2017 Jan 20;79(1):52-59. doi: 10.1292/jvms.16-0282. Epub 2016 Oct 30.
The association between pancreatic disorder and abdominal fat necrosis in cattle remains unclear. The pancreases of 29 slaughtered cattle with or without fat necrosis were collected to investigate pathological changes. Japanese Black (JB) cattle were classified into the FN group (with abdominal fat necrosis; n=9) and N group (without fat necrosis; n=5). The pancreases were also collected from 15 Holstein Friesian (HF) cows. All JB cattle showed high body condition scores. Regarding the pathological findings, fatty pancreas which involves adipocyte infiltration into the pancreas and fat necrosis (saponification) were observed in 25 and 27 cases, respectively. Immunohistochemical staining with anti-Iba-1 antibody showed large numbers of macrophages surrounding the saponified fat in the pancreas. CD3-positive T cells were significantly more common in the pancreas of both the FN and N groups compared with the HF group (P<0.05). Furthermore, fibrosis in the pancreas exhibited a correlative tendency with the formation of necrotic fat mass in the peritoneal cavity (P<0.1). These results indicate that obesity leads to increased severity of pancreatic disorder, including fatty pancreas and pancreatitis. The pathological lesions in the pancreas may play a key role in abdominal fat necrosis through the inflammatory process.
牛胰腺疾病与腹部脂肪坏死之间的关联仍不清楚。收集了29头有或没有脂肪坏死的屠宰牛的胰腺，以调查其病理变化。日本黑牛（JB）被分为FN组（有腹部脂肪坏死；n = 9）和N组（无脂肪坏死；n = 5）。还从15头荷斯坦弗里生牛（HF）奶牛身上收集了胰腺。所有JB牛的体况评分都很高。关于病理结果，分别在25例和27例中观察到脂肪胰腺，即脂肪细胞浸润到胰腺以及脂肪坏死（皂化）。用抗Iba-1抗体进行免疫组织化学染色显示，胰腺中皂化脂肪周围有大量巨噬细胞。与HF组相比，FN组和N组胰腺中CD3阳性T细胞明显更常见（P<0.05）。此外，胰腺纤维化与腹腔内坏死脂肪块的形成呈相关趋势（P<0.1）。这些结果表明，肥胖会导致胰腺疾病严重程度增加，包括脂肪胰腺和胰腺炎。胰腺的病理病变可能通过炎症过程在腹部脂肪坏死中起关键作用。
