锌和铜配位的多羟基查尔酮配合物的合成、表征及抗氧化活性
Synthesis, characterization, and antioxidant activity of Zn and Cu coordinated polyhydroxychalcone complexes.
作者信息
Sulpizio Chiara, Müller Simon T R, Zhang Qi, Brecker Lothar, Rompel Annette
机构信息
Institut für Biophysikalische Chemie, Fakultät für Chemie, Universität Wien, Althanstraße 14, 1090 Vienna, Austria.
Institut für Organische Chemie, Fakultät für Chemie, Universität Wien, Währinger Straße 38, 1090 Vienna, Austria.
出版信息
Monatsh Chem. 2016;147(11):1871-1881. doi: 10.1007/s00706-016-1822-7. Epub 2016 Aug 29.
ABSTRACT
Four new metal complexes [Cu(ISO)], [Cu(BUT)] and [Zn(ISO)], [Zn(BUT)] of the polyhydroxychalcones (isoliquiritigenin and butein) are synthesized, structurally characterized and their antioxidant activity is investigated. The formation of the complexes [Cu(ISO)] and [Zn(ISO)] is followed by Job's plot using NMR titration. The resulting compounds are characterized by mass spectrometry, IR spectroscopy, and elemental analysis. Studies on the radical scavenging activity are performed using DPPH as substrate. The results showed that the antioxidant activities of isoliquiritigenin and butein are enhanced after binding to copper or zinc.
摘要
合成了多羟基查耳酮（异甘草素和紫铆因）的四种新型金属配合物[Cu(ISO)]、[Cu(BUT)]以及[Zn(ISO)]、[Zn(BUT)]，对其进行了结构表征并研究了它们的抗氧化活性。采用NMR滴定法通过Job曲线跟踪配合物[Cu(ISO)]和[Zn(ISO)]的形成。通过质谱、红外光谱和元素分析对所得化合物进行了表征。以DPPH为底物进行了自由基清除活性研究。结果表明，异甘草素和紫铆因与铜或锌结合后抗氧化活性增强。
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