• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

锌和铜配位的多羟基查尔酮配合物的合成、表征及抗氧化活性

Synthesis, characterization, and antioxidant activity of Zn and Cu coordinated polyhydroxychalcone complexes.

作者信息

Sulpizio Chiara, Müller Simon T R, Zhang Qi, Brecker Lothar, Rompel Annette

机构信息

Institut für Biophysikalische Chemie, Fakultät für Chemie, Universität Wien, Althanstraße 14, 1090 Vienna, Austria.

Institut für Organische Chemie, Fakultät für Chemie, Universität Wien, Währinger Straße 38, 1090 Vienna, Austria.

出版信息

Monatsh Chem. 2016;147(11):1871-1881. doi: 10.1007/s00706-016-1822-7. Epub 2016 Aug 29.

DOI:10.1007/s00706-016-1822-7
PMID:27795583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5063914/
Abstract

ABSTRACT

Four new metal complexes [Cu(ISO)], [Cu(BUT)] and [Zn(ISO)], [Zn(BUT)] of the polyhydroxychalcones (isoliquiritigenin and butein) are synthesized, structurally characterized and their antioxidant activity is investigated. The formation of the complexes [Cu(ISO)] and [Zn(ISO)] is followed by Job's plot using NMR titration. The resulting compounds are characterized by mass spectrometry, IR spectroscopy, and elemental analysis. Studies on the radical scavenging activity are performed using DPPH as substrate. The results showed that the antioxidant activities of isoliquiritigenin and butein are enhanced after binding to copper or zinc.

摘要

摘要

合成了多羟基查耳酮（异甘草素和紫铆因）的四种新型金属配合物[Cu(ISO)]、[Cu(BUT)]以及[Zn(ISO)]、[Zn(BUT)]，对其进行了结构表征并研究了它们的抗氧化活性。采用NMR滴定法通过Job曲线跟踪配合物[Cu(ISO)]和[Zn(ISO)]的形成。通过质谱、红外光谱和元素分析对所得化合物进行了表征。以DPPH为底物进行了自由基清除活性研究。结果表明，异甘草素和紫铆因与铜或锌结合后抗氧化活性增强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/be54e1b457c2/706_2016_1822_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/4af8e18f04c9/706_2016_1822_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/b843d49e5933/706_2016_1822_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/ee7cc890b26a/706_2016_1822_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/836dc59efa53/706_2016_1822_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/be54e1b457c2/706_2016_1822_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/4af8e18f04c9/706_2016_1822_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/b843d49e5933/706_2016_1822_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/ee7cc890b26a/706_2016_1822_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/836dc59efa53/706_2016_1822_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/5063914/be54e1b457c2/706_2016_1822_Fig4_HTML.jpg

相似文献

1
Synthesis, characterization, and antioxidant activity of Zn and Cu coordinated polyhydroxychalcone complexes.锌和铜配位的多羟基查尔酮配合物的合成、表征及抗氧化活性
Monatsh Chem. 2016;147(11):1871-1881. doi: 10.1007/s00706-016-1822-7. Epub 2016 Aug 29.
2
Synthesis, spectral characterization and antioxidant activity studies of a bidentate Schiff base, 5-methyl thiophene-2-carboxaldehyde-carbohydrazone and its Cd(II), Cu(II), Ni(II) and Zn(II) complexes.合成、光谱表征及双齿席夫碱 5-甲基噻吩-2-甲醛缩氨基硫脲及其 Cd(II)、Cu(II)、Ni(II)和 Zn(II)配合物的抗氧化活性研究。
Spectrochim Acta A Mol Biomol Spectrosc. 2013 Jan 15;101:264-72. doi: 10.1016/j.saa.2012.09.085. Epub 2012 Oct 5.
3
Synthesis, characterization and antioxidant activity of naringenin Schiff base and its Cu(II), Ni(II), Zn(II) complexes.柚皮素席夫碱及其铜（II）、镍（II）、锌（II）配合物的合成、表征与抗氧化活性
Chem Pharm Bull (Tokyo). 2007 Jan;55(1):26-8. doi: 10.1248/cpb.55.26.
4
Spectroscopic properties of some new azo-azomethine ligands in the presence of Cu(2+), Pb(2+), Hg(2+), Co(2+), Ni(2+), Cd(2+) and Zn(2+) and their antioxidant activity.某些新型偶氮 - 偶氮甲碱配体在Cu(2+)、Pb(2+)、Hg(2+)、Co(2+)、Ni(2+)、Cd(2+)和Zn(2+)存在下的光谱性质及其抗氧化活性。
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Oct 15;131:67-71. doi: 10.1016/j.saa.2014.04.026. Epub 2014 Apr 18.
5
Synthesis of novel chiral metal complexes derived from chiral thiosemicarbazide ligands as potential antioxidant agents.新型手性硫代缩氨基脲配体衍生的手性金属配合物的合成及其作为潜在抗氧化剂的研究。
Chirality. 2019 Jun;31(6):434-444. doi: 10.1002/chir.23069. Epub 2019 Apr 11.
6
Synthesis, Spectral Characterization, SEM, Antimicrobial, Antioxidative Activity Evaluation, DNA Binding and DNA Cleavage Investigation of Transition Metal(II) Complexes Derived from a tetradentate Schiff base bearing thiophene moiety.噻吩基四齿席夫碱过渡金属（II）配合物的合成、光谱表征、SEM、抗菌、抗氧化活性评价、DNA 结合和 DNA 断裂研究。
J Fluoresc. 2017 May;27(3):1051-1066. doi: 10.1007/s10895-017-2039-9. Epub 2017 Mar 1.
7
Synthesis, Structure Characterization, and Antioxidant and Antibacterial Activity Study of Iso-orientin-Zinc Complex.异荭草素-锌配合物的合成、结构表征及其抗氧化和抗菌活性研究
J Agric Food Chem. 2021 Apr 7;69(13):3952-3964. doi: 10.1021/acs.jafc.0c06337. Epub 2021 Mar 25.
8
Studies on chalcone derivatives: complex formation, thermal behavior, stability constant and antioxidant activity.查尔酮衍生物的研究：络合物形成、热行为、稳定常数及抗氧化活性
Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 25;137:423-31. doi: 10.1016/j.saa.2014.08.061. Epub 2014 Sep 2.
9
Quinoxaline based bio-active mixed ligand transition metal complexes: Synthesis, characterization, electrochemical, antimicrobial, DNA binding, cleavage, antioxidant and molecular docking studies.基于喹喔啉的生物活性混合配体过渡金属配合物：合成、表征、电化学、抗菌、DNA结合、切割、抗氧化及分子对接研究
J Photochem Photobiol B. 2015 Oct;151:100-9. doi: 10.1016/j.jphotobiol.2015.07.010. Epub 2015 Jul 15.
10
Synthesis of new piperazine derived Cu(II)/Zn(II) metal complexes, their DNA binding studies, electrochemistry and anti-microbial activity: validation for specific recognition of Zn(II) complex to DNA helix by interaction with thymine base.新型哌嗪衍生的铜（II）/锌（II）金属配合物的合成、DNA结合研究、电化学及抗菌活性：通过与胸腺嘧啶碱基相互作用验证锌（II）配合物对DNA螺旋的特异性识别
Spectrochim Acta A Mol Biomol Spectrosc. 2009 Jun;72(5):1026-33. doi: 10.1016/j.saa.2008.12.037. Epub 2009 Jan 4.

引用本文的文献

1
Cytotoxicity and Antibacterial Potentials of Mixed Ligand Cu(II) and Zn(II) Complexes: A Combined Experimental and Computational Study.混合配体铜（II）和锌（II）配合物的细胞毒性和抗菌潜力：实验与计算相结合的研究
ACS Omega. 2023 Mar 29;8(14):13421-13434. doi: 10.1021/acsomega.3c00916. eCollection 2023 Apr 11.
2
Colorimetric Cu Detection of (1,2)-1,2-Bis((1-pyrrol-2-yl)methylene)hydrazine Using a Custom-Built Colorimeter.使用定制比色计对(1,2)-1,2-双((1-吡咯-2-基)亚甲基)肼进行比色法铜检测。
ACS Omega. 2022 Nov 23;7(48):44448-44457. doi: 10.1021/acsomega.2c06751. eCollection 2022 Dec 6.
3
Metallophenolomics: A Novel Integrated Approach to Study Complexation of Plant Phenolics with Metal/Metalloid Ions.

本文引用的文献

1
Xanthohumol, a main prenylated chalcone from hops, reduces liver damage and modulates oxidative reaction and apoptosis in hepatitis C virus infected Tupaia belangeri.葎草酮，一种来自啤酒花的主要类异戊二烯查尔酮，可减轻肝损伤并调节丙型肝炎病毒感染的褐鼯猴的氧化反应和细胞凋亡。
Int Immunopharmacol. 2013 Aug;16(4):466-74. doi: 10.1016/j.intimp.2013.04.029. Epub 2013 May 10.
2
Exploration of the medical periodic table: towards new targets.医学元素周期表的探索：寻求新靶点。
Chem Commun (Camb). 2013 Jun 7;49(45):5106-31. doi: 10.1039/c3cc41143e.
3
Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics.
金属酚组学：一种研究植物酚类与金属/类金属离子络合的新综合方法。
Int J Mol Sci. 2022 Sep 26;23(19):11370. doi: 10.3390/ijms231911370.
4
Mass Spectrometric Investigation of Organo-Functionalized Magnetic Nanoparticles Binding Properties toward Chalcones.有机功能化磁性纳米粒子与查耳酮结合特性的质谱研究
Materials (Basel). 2021 Aug 20;14(16):4705. doi: 10.3390/ma14164705.
作为潜在抗氧化酶模拟物的含吡唑衍生物的铜（II）配合物。
Med Chem Res. 2013 May;22(5):2395-2402. doi: 10.1007/s00044-012-0233-5. Epub 2012 Sep 26.
4
Metal binding ability of curcumin derivatives: a theoretical vs. experimental approach.姜黄素衍生物的金属结合能力：理论与实验研究。
Dalton Trans. 2013 Apr 21;42(15):5304-13. doi: 10.1039/c3dt33072a. Epub 2013 Feb 13.
5
Free radicals, antioxidants and functional foods: Impact on human health.自由基、抗氧化剂与功能性食品：对人类健康的影响。
Pharmacogn Rev. 2010 Jul;4(8):118-26. doi: 10.4103/0973-7847.70902.
6
Newly synthesized curcumin derivatives: crosstalk between chemico-physical properties and biological activity.新型姜黄素衍生物：化学物理性质与生物活性的相互作用。
J Med Chem. 2011 Dec 8;54(23):8066-77. doi: 10.1021/jm200872q. Epub 2011 Nov 11.
7
Structure of dihydrochalcones and related derivatives and their scavenging and antioxidant activity against oxygen and nitrogen radical species.二氢查耳酮类化合物及其相关衍生物的结构及其对氧和氮自由基物种的清除和抗氧化活性。
Molecules. 2011 Feb 21;16(2):1749-60. doi: 10.3390/molecules16021749.
8
Increased bioavailability of tricin-amino acid derivatives via a prodrug approach.通过前药方法提高荞麦黄酮氨基酸衍生物的生物利用度。
J Med Chem. 2011 Mar 10;54(5):1529-36. doi: 10.1021/jm1015457. Epub 2011 Feb 14.
9
Interaction of quercetin with copper ions: complexation, oxidation and reactivity towards radicals.槲皮素与铜离子的相互作用：络合、氧化及对自由基的反应性。
Biometals. 2011 Feb;24(1):41-9. doi: 10.1007/s10534-010-9372-7. Epub 2010 Sep 11.
10
[Review of pharmacological effects of Glycyrrhiza radix and its bioactive compounds].[甘草及其生物活性成分的药理作用综述]
Zhongguo Zhong Yao Za Zhi. 2009 Nov;34(21):2695-700.