Wasilewski Tomasz, Seweryn Artur, Krajewski Maciej
Department of Chemistry, Kazimierz Pulaski University of Technology and Humanities, ul. Boleslawa Chrobrego 27, Radom, 26-600 Poland.
J Surfactants Deterg. 2016;19(6):1315-1326. doi: 10.1007/s11743-016-1868-x. Epub 2016 Sep 1.
We investigated the effect of hydrophobic extract concentration on the safety of using hand dishwashing liquids (HDL). A series of formulations was prepared, differing in the concentration of the hydrophobic chamomile extract obtained in supercritical CO conditions (from 0 to 0.7 %). We found that an increase in the concentration of the extract led to a decrease in the zein number, and reduced changes in the pH level of bovine serum albumin solution (i.e., two parameters determining the irritant activity of the formulations). It was also found that the additives reduced transepidermal water loss and improved the skin hydration level. Based on the findings of the study, a mechanism has been proposed, according to which hydrophobic plant extracts form aggregates in the volume phase of the washing bath. The surface of the aggregates is the adsorption area for surfactant monomers responsible for the irritant effect. Increasing the addition of the extract was shown to reduce the negative impact of the formulations on the skin of the hands, thus contributing to a greater safety of use of HDL.
我们研究了疏水提取物浓度对使用餐具洗涤剂（HDL）安全性的影响。制备了一系列配方，其超临界CO₂条件下获得的疏水草药提取物浓度不同（从0至0.7%）。我们发现提取物浓度的增加导致玉米醇溶蛋白值降低，并减少了牛血清白蛋白溶液pH值的变化（即确定配方刺激活性的两个参数）。还发现这些添加剂减少了经表皮水分流失并改善了皮肤水合水平。基于该研究结果，提出了一种机制，据此疏水性植物提取物在洗涤浴的体相中形成聚集体。聚集体的表面是负责刺激作用的表面活性剂单体的吸附区域。增加提取物的添加量可降低配方对手部皮肤的负面影响，从而提高餐具洗涤剂使用的安全性。
