Carrier Alice
CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Aix Marseille University , Marseille, France .
Antioxid Redox Signal. 2017 Mar 20;26(9):429-431. doi: 10.1089/ars.2016.6929. Epub 2016 Dec 19.
The worldwide epidemic of obesity is a major public health concern. Obesity is a major risk factor for noncommunicable diseases such as type 2 diabetes and cardiovascular diseases, clustered in the so-called metabolic syndrome (MS). Other main chronic illnesses are promoted by excessive body weight, including cancer and neurodegenerative pathologies, both affecting a number of people worldwide. In recent years, the primary role of an excess of reactive oxygen species (oxidative stress) resulting from altered redox control in the etiology of all of these pathologies has been unveiled. Interestingly, it appears that oxidative stress is both the cause and the consequence of obesity and associated disorders. This Forum features reviews that recapitulate the current knowledge on the link between oxidative stress and MS in the physiopathology of different biological systems. Antioxid. Redox Signal. 26, 429-431.
全球肥胖流行是一个主要的公共卫生问题。肥胖是2型糖尿病和心血管疾病等非传染性疾病的主要危险因素，这些疾病聚集在所谓的代谢综合征（MS）中。其他主要慢性病也因体重过重而增加，包括癌症和神经退行性疾病，这两种疾病在全球都影响着许多人。近年来，已经揭示了氧化还原控制改变导致的活性氧过量（氧化应激）在所有这些疾病病因中的主要作用。有趣的是，氧化应激似乎既是肥胖及相关疾病的原因，也是其结果。本论坛的综述总结了目前关于氧化应激与不同生物系统生理病理学中MS之间联系的知识。《抗氧化与氧化还原信号》第26卷，第429 - 431页。
