Li Yu-Qing, Li Ping, Chu Ran, Tian Wei-Wei, Wang Jia-Xin, Liu Yin, Gao Jing
Clinical School of Thoracic, Tianjin Medical University, No.22 Qi Xiangtai Road, Heping District, Tianjin, 300070, People's Republic of China.
Cardiovascular Institute, Tianjin Chest Hospital, No.261 Tai Erzhuang Road, Jinnan District, Tianjin, 300222, People's Republic of China.
Sci Rep. 2025 Mar 18;15(1):9258. doi: 10.1038/s41598-025-90640-w.
Anti-oxidant/Pro-oxidant oxidant imbalance leads to chronic inflammation and insulin resistance can lead to the development of metabolic syndrome (MetS). The oxidative balance score (OBS) is a tool for assessing oxidative stress associated with MetS risk. However, the association between OBS and mortality in patients with MetS remains unclear. This study analyzed 10,647 MetS patients from the 1999-2018 National Health and Nutrition Examination Survey (NHANES). OBS were calculated using a combination of 16 dietary and 4 lifestyle factors. Multivariate Cox proportional hazards regression models, Kaplan-Meier survival analysis, restricted cubic splines (RCS), and subgroup analyses were used to evaluate the potential association between OBS and the risk of all-cause and cardiovascular mortality. Sensitivity analyses confirmed the robustness of the results. This study found that OBS was inversely associated with all-cause and cardiovascular mortality in patients with MetS, a result consistent across most subgroups. Both the Kaplan-Meier curve and RCS analysis supported these findings. Sensitivity analysis was used to verify the robustness of the results. Maintaining an antioxidant-based diet and lifestyle may help reduce the risk of all-cause and cardiovascular mortality in patients with MetS. These findings underscore the significance of incorporating antioxidant-rich dietary patterns and behavioral practices in strategies aimed at preventing and managing MetS.
抗氧化剂/促氧化剂失衡会导致慢性炎症，而胰岛素抵抗会引发代谢综合征（MetS）。氧化平衡评分（OBS）是一种评估与MetS风险相关的氧化应激的工具。然而，OBS与MetS患者死亡率之间的关联仍不明确。本研究分析了1999 - 2018年国家健康与营养检查调查（NHANES）中的10647例MetS患者。OBS通过16种饮食和4种生活方式因素的组合来计算。采用多变量Cox比例风险回归模型、Kaplan - Meier生存分析、限制性立方样条（RCS）和亚组分析来评估OBS与全因死亡率和心血管死亡率风险之间的潜在关联。敏感性分析证实了结果的稳健性。本研究发现，OBS与MetS患者的全因死亡率和心血管死亡率呈负相关，这一结果在大多数亚组中一致。Kaplan - Meier曲线和RCS分析均支持这些发现。使用敏感性分析来验证结果的稳健性。保持以抗氧化剂为基础的饮食和生活方式可能有助于降低MetS患者的全因死亡率和心血管死亡率风险。这些发现强调了在预防和管理MetS的策略中纳入富含抗氧化剂的饮食模式和行为习惯的重要性。
