美国成年人中过度肥胖与1型和2型单纯疱疹病毒血清流行率之间的关联：一项基于人群的年龄-时期-队列分析。

Associations between excessive adiposity and seroprevalence of herpes simplex virus type 1 and type 2 among US adults: a population-based age-period-cohort analysis.

作者信息

Liu Su-Hsun, Tzeng I-Shiang, Hsieh Tsung-Han, Huang Yhu-Chering

机构信息

College of Medicine, Chang Gung University, Taoyuan City, Taiwan.

Department of Family Medicine, Chang Gung Memorial Hospital, Taoyuan City, Taiwan.

出版信息

BMJ Open. 2016 Oct 17;6(10):e012571. doi: 10.1136/bmjopen-2016-012571.

DOI:10.1136/bmjopen-2016-012571

PMID:27798014

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5073520/

Abstract

OBJECTIVES

Evidence on the association between herpes simplex virus (HSV) and excessive adiposity, such as obesity (body mass index ≥30 kg/m) and abdominal obesity (waist circumference (WC) >102 or 88 cm), has been inconsistent. We sought to examine whether age-period-cohort (APC) effects could explain for the observed heterogeneities.

DESIGN

Population-based cross-sectional study.

PARTICIPANTS

Adults aged 20-49 years with available serological data in the National Health and Nutrition Examination Survey (NHANES) in 1999-2012.

EXPOSURE MEASURES

Obesity and abdominal obesity.

RESULTS

In men, excessive adiposity was generally not associated with HSV1 or HSV2 (all p>0.05); however, there were positive correlations between HSV seroprevalence and excessive adiposity in certain age and birth cohort groups. Based on APC analysis, abdominally obese men aged 30-40 years showed a nearly 20% increase in risk for HSV1 seropositivity (adjusted prevalence ratio (aPR)=1.18; 95% CI 1.10 to 1.27) as compared with abdominally non-obese men of the same age; there was no such association in men of other age groups. Also, men of a large WC who were born before 1962 or after 1979 had a 28% higher risk for HSV2 seropositivity than those of a normal WC in the same birth cohorts (aPR=1.28, 95% CI 1.17 to 1.54); yet the association did not hold for men in other cohorts (aPR=0.86, 95% CI 0.64 to 1.17). In women, a large WC was correlated with a minimally increased HSV1 seroprevalence (aPR=1.07, 95% CI 1.01 to 1.13) but not with HSV2 seropositivity (aPR=1.13; 95% CI 0.99 to 1.28). Likewise, there were strong associations between abdominal obesity and HSV2 seropositivity in subgroups of women participating in the earliest survey cycle (aPR=1.41, 95% CI 1.12 to 1.78) but not in other survey periods (aPR=0.94, 95% CI 0.85 to 1.03).

CONCLUSIONS

There was no consistent evidence for strong associations between HSV seropositivity and excessive adiposity in adults. APC analysis results further cautioned the generalisability of previous reports based on 1 or 2 cycles of survey data.

摘要

目的

关于单纯疱疹病毒（HSV）与过度肥胖（如肥胖症，体重指数≥30 kg/m²）和腹型肥胖（腰围（WC）>102或88 cm）之间关联的证据并不一致。我们试图研究年龄-时期-队列（APC）效应是否可以解释所观察到的异质性。

设计

基于人群的横断面研究。

参与者

1999 - 2012年美国国家健康与营养检查调查（NHANES）中年龄在20 - 49岁且有可用血清学数据的成年人。

暴露测量

肥胖症和腹型肥胖。

结果

在男性中，过度肥胖一般与HSV1或HSV2无关（所有p>0.05）；然而，在某些年龄和出生队列组中，HSV血清阳性率与过度肥胖之间存在正相关。基于APC分析，30 - 40岁的腹型肥胖男性与同年龄的非腹型肥胖男性相比，HSV1血清阳性的风险增加了近20%（调整患病率比（aPR）=1.18；95%可信区间1.10至1.27）；其他年龄组的男性则无此关联。此外，WC较大且出生于1962年之前或1979年之后的男性，与同出生队列中WC正常的男性相比，HSV2血清阳性的风险高28%（aPR=1.28，95%可信区间1.17至1.54）；但其他队列的男性不存在这种关联（aPR=0.86，95%可信区间0.64至1.17）。在女性中，WC较大与HSV-1血清阳性率略有增加相关（aPR=1.07，95%可信区间1.01至1.13），但与HSV2血清阳性无关（aPR=1.13；95%可信区间0.99至1.28）。同样，在参与最早调查周期的女性亚组中，腹型肥胖与HSV2血清阳性之间存在强关联（aPR=1.41，95%可信区间1.12至1.78），但在其他调查时期则不存在（aPR=0.94，95%可信区间0.85至1.03）。