Correa Fernando, Wolfson Manuel L, Valchi Paula, Aisemberg Julieta, Franchi Ana María
Center for Pharmacological and Botanical StudiesNational Research Council, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
Center for Pharmacological and Botanical StudiesNational Research Council, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
Reproduction. 2016 Dec;152(6):R191-R200. doi: 10.1530/REP-16-0167.
The endocannabinoid system (eCS), is a complex system, comprising the main endogenous ligands anandamide and 2-arachidonoyl glycerol, the cannabinoid receptors CB1 and CB2 and the biosynthetic and degrading enzymes. Cumulative evidence shows that the eCS plays an important role in reproduction, from egg fertilization to parturition. Therefore, alterations in this system, either by recreation/therapeutic use of cannabis or deregulation of the endogenous cannabinoids, might lead to adverse pregnancy outcomes, including retardation in embryo development, poor blastocyst implantation, inhibition of decidualization, miscarriage and compromised placentation. Nevertheless, the molecular mechanisms by which the eCS participates in different stages of pregnancy remain poorly understood. In this review, we will examine the evidence from animal and human studies to support the role of the eCS in implantation, early-to-late pregnancy and placentation as well as the difficulties of targeting this system for treatment of female infertility.
内源性大麻素系统（eCS）是一个复杂的系统，由主要的内源性配体花生四烯乙醇胺和2-花生四烯酸甘油、大麻素受体CB1和CB2以及生物合成和降解酶组成。越来越多的证据表明，eCS在从卵子受精到分娩的生殖过程中发挥着重要作用。因此，该系统的改变，无论是通过大麻的消遣/治疗性使用还是内源性大麻素的失调，都可能导致不良的妊娠结局，包括胚胎发育迟缓、胚泡着床不佳、蜕膜化抑制、流产和胎盘形成受损。然而，eCS参与妊娠不同阶段的分子机制仍知之甚少。在这篇综述中，我们将研究来自动物和人类研究的证据，以支持eCS在着床、妊娠早期到晚期以及胎盘形成中的作用，以及针对该系统治疗女性不孕症的困难。
