Isiten Havva Nuket, Cebi Merve, Sutcubasi Kaya Bernis, Metin Baris, Tarhan Nevzat
1 Department of Child and Adolescent Psychiatry, NPIstanbul Neuropsychiatry Hospital, Istanbul, Turkey.
2 Department of Psychology, Uskudar University, Istanbul, Turkey.
Clin EEG Neurosci. 2017 Jul;48(4):246-250. doi: 10.1177/1550059416675232. Epub 2016 Oct 25.
EEG biomarkers have become increasingly used to aid in diagnosis of attention-deficit/hyperactivity disorder (ADHD). Despite several studies suggesting that EEG theta/beta ratio may help discriminating ADHD from other disorders, the effect of medications on theta/beta ratio is not known. Forty-three children with ADHD that were evaluated with quantitative EEG before and after methylphenidate were included in the study. Theta/beta ratio, theta and beta powers for whole brain, central, and frontal areas were calculated. Theta/beta power decreased significantly after treatment; however, this change was largely due to an increase in beta power, rather than a fall in theta power. The results suggest that beta power is sensitive to medication effects, while theta power remains as a trait biomarker unaffected by medication status. The value of EEG biomarkers for monitoring neuropsychological performance and clinical status should be explored by future studies.
脑电图生物标志物越来越多地用于辅助注意力缺陷多动障碍（ADHD）的诊断。尽管有多项研究表明脑电图θ/β比值可能有助于将ADHD与其他疾病区分开来，但药物对θ/β比值的影响尚不清楚。本研究纳入了43名患有ADHD的儿童，他们在服用哌甲酯前后接受了定量脑电图评估。计算了全脑、中央区和额叶区域的θ/β比值、θ波和β波功率。治疗后θ/β功率显著降低；然而，这种变化主要是由于β波功率增加，而非θ波功率下降。结果表明，β波功率对药物作用敏感，而θ波功率作为一种特质生物标志物不受药物状态影响。未来的研究应探索脑电图生物标志物在监测神经心理表现和临床状态方面的价值。
