腹腔镜手术与开放手术治疗晚期直肠癌的临床及肿瘤学结局
Clinical and Oncological Outcomes of Laparoscopic Versus Open Surgery for Advanced Rectal Cancer.
作者信息
Nonaka Takashi, Fukuda Akiko, Maekawa Kyoichiro, Nagayoshi Shigeki, Tokunaga Takayuki, Takatsuki Mitsuhisa, Kitajima Tomoo, Taniguchi Ken, Fujioka Hikaru
机构信息
Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan
Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
出版信息
Anticancer Res. 2016 Oct;36(10):5419-5424. doi: 10.21873/anticanres.11119.
AIM
To compare the clinical and oncological outcomes of laparoscopic and open approaches in patients with advanced rectal cancer.
PATIENTS AND METHODS
In this study, 78 patients who underwent surgery for advanced middle and lower rectal cancer (pStage II - III) were divided into two groups according to type of surgical approach: laparoscopic surgery (LS group; n=40) and open surgery (OS group: n=38). The clinical outcomes and oncological outcomes were compared between the two groups.
RESULTS
The operation time was comparable, whereas operative blood loss and complication rates were significantly less in the LS group compared to the OS group. Cancer-specific survival (CSS) and local recurrence-free survival (LRFS) were similar in the two groups. Disease-free survival (DFS) was better in the LS group than in the OS group.
CONCLUSION
LS for advanced rectal cancer was safe and not inferior to OS in clinical and oncological outcomes.
目的
比较晚期直肠癌患者腹腔镜手术和开放手术的临床及肿瘤学结局。
患者与方法
本研究中，78例行中低位晚期直肠癌（p分期II - III期）手术的患者，根据手术方式分为两组：腹腔镜手术组（LS组；n = 40）和开放手术组（OS组：n = 38）。比较两组的临床结局和肿瘤学结局。
结果
两组手术时间相当，但与OS组相比，LS组术中失血量和并发症发生率显著更低。两组的癌症特异性生存率（CSS）和无局部复发生存率（LRFS）相似。LS组的无病生存率（DFS）优于OS组。
结论
晚期直肠癌的腹腔镜手术安全，在临床和肿瘤学结局方面不劣于开放手术。
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