一株人源腐生葡萄球菌中新型erm(44)基因变体赋予对大环内酯类和林可酰胺类抗生素的抗性，但对链阳菌素不产生抗性。
A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins.
作者信息
Strauss Christian, Hu Yanmin, Coates Anthony, Perreten Vincent
机构信息
Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.
Institute for Infection and Immunity, St George's, University of London, London, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2016 Dec 27;61(1). doi: 10.1128/AAC.01655-16. Print 2017 Jan.
Abstract
A novel erm(44) gene variant, erm(44), has been identified by whole-genome sequencing in a Staphylococcus saprophyticus isolate from the skin of a healthy person. It has the particularity to confer resistance to macrolides and lincosamides but not to streptogramin B when expressed in S. aureus The erm(44) gene resides on a 19,400-bp genomic island which contains phage-associated proteins and is integrated into the chromosome of S. saprophyticus.
摘要
通过全基因组测序，在一名健康人的皮肤腐生葡萄球菌分离株中鉴定出一种新的erm(44)基因变体erm(44)。当在金黄色葡萄球菌中表达时，它具有赋予对大环内酯类和林可酰胺类耐药性但对链阳菌素B不耐药的特性。erm(44)基因位于一个19400碱基对的基因组岛上，该岛包含噬菌体相关蛋白，并整合到腐生葡萄球菌的染色体中。
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