三阴性乳腺癌患者的新型治疗策略。
Novel therapeutic strategies for patients with triple-negative breast cancer.
作者信息
Zhang Jun-Fei, Liu Jia, Wang Yu, Zhang Bin
机构信息
Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, People's Republic of China.
Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, People's Republic of China; Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, People's Republic of China.
出版信息
Onco Targets Ther. 2016 Oct 21;9:6519-6528. doi: 10.2147/OTT.S105716. eCollection 2016.
Abstract
Triple-negative breast cancer (TNBC) represents a very heterogeneous group of breast diseases. Currently, the backbone of therapy for TNBC is mainly chemotherapy as there are no effective specific targeted agents approved to treat TNBC. Despite initial responses to chemotherapy, resistance frequently and rapidly develops and metastatic TNBC has a poor prognosis. Therefore, new targeted strategies are, accordingly, urgently needed. This article discusses the recent developments in targeted agents explored for TNBC, aiming to offer novel therapeutic strategies that can potentially assist in designing personalized therapeutics in the future as well as provide the basis for further research in an attempt to target TNBC.
摘要
三阴性乳腺癌（TNBC）是一组非常异质性的乳腺疾病。目前，TNBC的治疗主要以化疗为主，因为尚无经批准用于治疗TNBC的有效特异性靶向药物。尽管对化疗有初始反应，但耐药性经常迅速出现，转移性TNBC的预后较差。因此，迫切需要新的靶向治疗策略。本文讨论了针对TNBC探索的靶向药物的最新进展，旨在提供新的治疗策略，这些策略可能有助于未来设计个性化治疗方案，并为进一步针对TNBC的研究提供基础。
相似文献
1
Novel therapeutic strategies for patients with triple-negative breast cancer.三阴性乳腺癌患者的新型治疗策略。
Onco Targets Ther. 2016 Oct 21;9:6519-6528. doi: 10.2147/OTT.S105716. eCollection 2016.
2
Targeted Therapies in Triple-Negative Breast Cancer.三阴性乳腺癌的靶向治疗
Breast Care (Basel). 2015 Jul;10(3):159-66. doi: 10.1159/000433622. Epub 2015 Jun 24.
3
Metastatic triple negative breast cancer: Optimizing treatment options, new and emerging targeted therapies.转移性三阴性乳腺癌：优化治疗方案，新型及新兴靶向治疗
Asia Pac J Clin Oncol. 2018 Feb;14(1):32-39. doi: 10.1111/ajco.12748. Epub 2017 Aug 16.
4
Immunotherapy for triple-negative breast cancer: Existing challenges and exciting prospects.三阴性乳腺癌的免疫治疗：现存挑战与振奋前景。
Drug Resist Updat. 2017 May;32:1-15. doi: 10.1016/j.drup.2017.07.002. Epub 2017 Aug 19.
5
RNA-Based Therapeutics: Current Developments in Targeted Molecular Therapy of Triple-Negative Breast Cancer.基于RNA的疗法：三阴性乳腺癌靶向分子治疗的当前进展
Pharmaceutics. 2021 Oct 15;13(10):1694. doi: 10.3390/pharmaceutics13101694.
6
Long non-coding RNAs: implications in targeted diagnoses, prognosis, and improved therapeutic strategies in human non- and triple-negative breast cancer.长非编码 RNA：在人类非三阴性和三阴性乳腺癌的靶向诊断、预后和改进治疗策略中的意义。
Clin Epigenetics. 2018 Jun 27;10:88. doi: 10.1186/s13148-018-0514-z. eCollection 2018.
7
Recent therapeutic trends and promising targets in triple negative breast cancer.三阴性乳腺癌的最新治疗趋势和有前途的靶点。
Pharmacol Ther. 2019 Jul;199:30-57. doi: 10.1016/j.pharmthera.2019.02.006. Epub 2019 Feb 28.
8
Current strategy for triple-negative breast cancer: appropriate combination of surgery, radiation, and chemotherapy.三阴性乳腺癌的现行治疗策略：手术、放疗和化疗的适当结合。
Breast Cancer. 2011 Jul;18(3):165-73. doi: 10.1007/s12282-011-0254-9. Epub 2011 Feb 3.
9
Targeted Therapies for Triple-Negative Breast Cancer.三阴性乳腺癌的靶向治疗。
Curr Treat Options Oncol. 2019 Nov 21;20(11):82. doi: 10.1007/s11864-019-0682-x.
10
Genetic Markers in Triple-Negative Breast Cancer.三阴性乳腺癌的遗传标志物。
Clin Breast Cancer. 2018 Oct;18(5):e841-e850. doi: 10.1016/j.clbc.2018.07.023. Epub 2018 Aug 4.
引用本文的文献
1
SBFI-26 enhances apoptosis in docetaxel-treated triple-negative breast cancer cells by increasing ROS levels.SBFI-26通过提高活性氧水平增强多西他赛处理的三阴性乳腺癌细胞的凋亡。
Bioimpacts. 2024 Apr 30;15:30137. doi: 10.34172/bi.30137. eCollection 2025.
2
A triple combination gemcitabine + romidepsin + cisplatin to effectively control triple-negative breast cancer tumor development, recurrence, and metastasis.吉西他滨+罗米地辛+顺铂三联疗法可有效控制三阴性乳腺癌肿瘤的发展、复发和转移。
Cancer Chemother Pharmacol. 2021 Sep;88(3):415-425. doi: 10.1007/s00280-021-04298-y. Epub 2021 May 27.
3
Selection of aptamers against triple negative breast cancer cells using high throughput sequencing.高通量测序筛选三阴性乳腺癌细胞的适体。
Sci Rep. 2021 Apr 21;11(1):8614. doi: 10.1038/s41598-021-87998-y.
4
Narrowing the focus: Therapeutic cell surface targets for refractory triple-negative breast cancer.聚焦缩小：难治性三阴性乳腺癌的治疗性细胞表面靶点
World J Clin Oncol. 2020 Apr 24;11(4):169-179. doi: 10.5306/wjco.v11.i4.169.
5
Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis and is Traceable in the Circulating Extracellular Vesicles.癌症睾丸抗原促进三阴性乳腺癌转移，并可在外泌体中追踪。
Sci Rep. 2019 Aug 12;9(1):11632. doi: 10.1038/s41598-019-48064-w.
6
SOX2 Promotes Cell Proliferation and Metastasis in Triple Negative Breast Cancer.SOX2促进三阴性乳腺癌细胞的增殖和转移。
Front Pharmacol. 2018 Aug 21;9:942. doi: 10.3389/fphar.2018.00942. eCollection 2018.
7
Subtyping Of Triple Negative Breast Carcinoma On The Basis Of RTK Expression.基于受体酪氨酸激酶（RTK）表达的三阴性乳腺癌亚型分析
J Cancer. 2018 Jun 23;9(15):2589-2602. doi: 10.7150/jca.23023. eCollection 2018.
8
The Predictive Value of DNA Methylation for High-Risk Breast Cancer Therapy: Current Guidelines, Medical Needs, and Challenges.DNA 甲基化对高危乳腺癌治疗的预测价值：当前指南、医学需求和挑战。
Dis Markers. 2017;2017:4934608. doi: 10.1155/2017/4934608. Epub 2017 Sep 12.
9
SR-B1-targeted nanodelivery of anti-cancer agents: a promising new approach to treat triple-negative breast cancer.针对SR-B1的抗癌药物纳米递送：一种治疗三阴性乳腺癌的有前景的新方法。
Breast Cancer (Dove Med Press). 2017 Jun 2;9:383-392. doi: 10.2147/BCTT.S131038. eCollection 2017.
10
Emerging Cytotoxic Alkaloids in the Battle against Cancer: Overview of Molecular Mechanisms.抗癌斗争中新兴的细胞毒性生物碱：分子机制概述
Molecules. 2017 Feb 8;22(2):250. doi: 10.3390/molecules22020250.
本文引用的文献
1
Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer.靶向JAK2、PD-L1和PD-L2的9p24.1基因组扩增在高危三阴性乳腺癌中富集。
Oncotarget. 2015 Sep 22;6(28):26483-93. doi: 10.18632/oncotarget.4494.
2
Triple-negative breast cancer: immune modulation as the new treatment paradigm.三阴性乳腺癌：免疫调节作为新的治疗模式。
Am Soc Clin Oncol Educ Book. 2015:e25-30. doi: 10.14694/EdBook_AM.2015.35.e25.
3
Immune targeting in breast cancer.乳腺癌中的免疫靶向治疗
Oncology (Williston Park). 2015 May;29(5):375-85.
4
Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Therapy for Triple-Negative and BRCA1/2 Mutation-Associated Breast Cancer With Assessment of a Tumor-Based Measure of Genomic Instability: PrECOG 0105.吉西他滨、卡铂和依尼帕利作为三阴性及BRCA1/2突变相关乳腺癌新辅助治疗的II期研究，并评估基于肿瘤的基因组不稳定性指标：PrECOG 0105。
J Clin Oncol. 2015 Jun 10;33(17):1895-901. doi: 10.1200/JCO.2014.57.0085. Epub 2015 Apr 6.
5
CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis.CIP4促进三阴性乳腺癌转移，并与患者预后不良相关。
Oncotarget. 2015 Apr 20;6(11):9397-408. doi: 10.18632/oncotarget.3351.
6
Targeting thyroid hormone receptor beta in triple-negative breast cancer.针对三阴性乳腺癌中的甲状腺激素受体β
Breast Cancer Res Treat. 2015 Apr;150(3):535-45. doi: 10.1007/s10549-015-3354-y. Epub 2015 Mar 28.
7
Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways.雷公藤红素对人三阴性乳腺癌的抗癌作用：可能涉及氧化应激、线粒体功能障碍、细胞凋亡和PI3K/Akt信号通路。
Exp Mol Pathol. 2015 Jun;98(3):313-27. doi: 10.1016/j.yexmp.2015.03.031. Epub 2015 Mar 26.
8
FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells.粘着斑激酶（FAK）激活是胰岛素样生长因子1受体（IGF1R）介导的间充质三阴性乳腺癌细胞上皮-间质转化（EMT）、迁移和侵袭调控所必需的。
Oncotarget. 2015 Mar 10;6(7):4757-72. doi: 10.18632/oncotarget.3023.
9
Exercise and dietary advice intervention for survivors of triple-negative breast cancer: effects on body fat, physical function, quality of life, and adipokine profile.三阴性乳腺癌幸存者的运动与饮食建议干预：对体脂、身体功能、生活质量和脂肪因子谱的影响
Support Care Cancer. 2015 Oct;23(10):2995-3003. doi: 10.1007/s00520-015-2667-z. Epub 2015 Mar 1.
10
Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer.肿瘤微环境的调节与EGF/EGFR通路的抑制：大麻二酚在乳腺癌中的新型抗肿瘤机制
Mol Oncol. 2015 Apr;9(4):906-19. doi: 10.1016/j.molonc.2014.12.010. Epub 2015 Jan 19.
Zotero 插件