Moro F, Secchi A G, Moschini G B, Pinello L, Sotti G, Zanesco L
Institute of Ophthalmology, Padova University, Italy.
Ophthalmic Paediatr Genet. 1989 Jun;10(2):107-9. doi: 10.3109/13816818909088350.
The authors report their experience in the treatment of 21 children affected by retinoblastoma. There were 14 bilateral and seven unilateral cases of retinoblastoma; mean age at diagnosis was 16 months in males (16 patients) and 30 months in females (five patients). They were all staged according to Howarth et al. (1980) and treatment was correlated to the various stages. The treatment protocol was determined by a group of co-workers at the University of Padova. Among the 35 affected eyes, 26 were enucleated and the others were treated without surgery. One patient died of cerebral metastases and two patients are affected by a second tumor with an unfavorable prognosis for survival. Two other patients are affected by chronic liver disease, probably due to chemotherapy. The authors confirm the importance of early diagnosis and prompt and effective treatment in children affected by retinoblastoma. They also stress that recently developed genetic techniques allow diagnosis of retinoblastoma even before the symptoms appear.
作者报告了他们治疗21例视网膜母细胞瘤患儿的经验。其中视网膜母细胞瘤双侧病例14例，单侧病例7例；男性（16例）诊断时的平均年龄为16个月，女性（5例）为30个月。所有病例均按照豪沃思等人（1980年）的方法进行分期，治疗与不同分期相关。治疗方案由帕多瓦大学的一组同事确定。在35只患眼中，26只眼被摘除，其他眼未接受手术治疗。1例患者死于脑转移，2例患者患有对生存预后不利的第二种肿瘤。另外2例患者患有慢性肝病，可能是化疗所致。作者证实了早期诊断以及对视网膜母细胞瘤患儿进行及时有效治疗的重要性。他们还强调，最近开发的基因技术甚至能在症状出现之前诊断出视网膜母细胞瘤。
