Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Invest Ophthalmol Vis Sci. 2013 Jul 10;54(7):4478-84. doi: 10.1167/iovs.12-11268.
We compared the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect glaucoma.
We enrolled 87 normal eyes and 145 glaucomatous eyes (75 early glaucomatous eyes (EGs), mean deviation > -6 dB). Each participant was imaged using Cirrus, RTVue, and 3D-OCT to evaluate the average and quadrant cpRNFL thicknesses. The macular retinal nerve fiber layer (mRNFL), ganglion cell layer plus inner plexiform layer (GCL/IPL), and mRNFL + GCL/IPL (ganglion cell complex [GCC]) thicknesses were analyzed. The areas under the receiver operating characteristic curves (AUCs) were compared among the instruments.
These instruments revealed similar AUCs for the average cpRNFL and GCC thicknesses in EGs, and total all-stage glaucomatous eyes (TGs). RTVue showed better performance in the nasal cpRNFL thickness than Cirrus and 3D-OCT, and better performance in the temporal cpRNFL thickness than 3D-OCT in TGs. RTVue had a higher AUC for the superior GCC thickness compared to Cirrus and 3D-OCT in EGs, and TGs. Cirrus had higher AUCs for GCL/IPL parameters in TGs, and lower AUCs for the mRNFL parameters in EGs and TGs compared to 3D-OCT.
The average cpRNFL and GCC thicknesses measured using these OCT instruments exhibited similar abilities in the diagnosis of glaucoma, and RTVue exhibited better diagnostic abilities than Cirrus and 3D-OCT for nasal cpRNFL, and superior GCC thicknesses. The diagnostic performance of Cirrus and 3D-OCT was different for GCL/IPL and mRNFL parameters. (http://www.umin.ac.jp/ctr number, UMIN000006900.)
我们比较了三种谱域光相干断层扫描（SD-OCT）仪器获得的周边视网膜神经纤维层（cpRNFL）厚度和黄斑参数检测青光眼的能力。
我们纳入了 87 只正常眼和 145 只青光眼眼（75 只早期青光眼眼（EGs），平均偏差>-6 dB）。每位参与者均使用 Cirrus、RTVue 和 3D-OCT 进行成像，以评估平均和象限 cpRNFL 厚度。分析黄斑视网膜神经纤维层（mRNFL）、神经节细胞层加内丛状层（GCL/IPL）和 mRNFL+GCL/IPL（神经节细胞复合体[GCC]）厚度。比较仪器之间的受试者工作特征曲线（AUC）下面积。
这些仪器在 EGs 和总所有阶段青光眼眼（TGs）中，平均 cpRNFL 和 GCC 厚度的 AUC 相似。RTVue 在鼻侧 cpRNFL 厚度方面优于 Cirrus 和 3D-OCT，在颞侧 cpRNFL 厚度方面优于 3D-OCT。在 EGs 和 TGs 中，RTVue 上方 GCC 厚度的 AUC 高于 Cirrus 和 3D-OCT。Cirrus 在 TGs 中具有更高的 GCL/IPL 参数 AUC，而在 EGs 和 TGs 中 mRNFL 参数的 AUC 较低。
这些 OCT 仪器测量的平均 cpRNFL 和 GCC 厚度在青光眼诊断中具有相似的能力，与 Cirrus 和 3D-OCT 相比，RTVue 在鼻侧 cpRNFL 和上方 GCC 厚度方面具有更好的诊断能力。Cirrus 和 3D-OCT 在 GCL/IPL 和 mRNFL 参数方面的诊断性能不同。（http://www.umin.ac.jp/ctr number，UMIN000006900。）
