两例接种人乳头瘤病毒疫苗后发生的急性播散性脑脊髓炎
Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus.
作者信息
Sekiguchi Kenji, Yasui Naoko, Kowa Hisatomo, Kanda Fumio, Toda Tatsushi
机构信息
Division of Neurology, Kobe University Graduate School of Medicine, Japan.
出版信息
Intern Med. 2016;55(21):3181-3184. doi: 10.2169/internalmedicine.55.5472. Epub 2016 Nov 1.
We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.
我们在此报告两例接种人乳头瘤病毒（HPV）疫苗后发生急性播散性脑脊髓炎（ADEM）的病例。病例1在第二次接种卉妍康疫苗14天后出现复视并步态不稳。脑部磁共振成像（MRI）显示脑桥被盖部有一个孤立的小脱髓鞘病变。病例2在第二次接种加德西疫苗16天后出现发热和肢体感觉异常。脑部MRI在T2加权图像上显示脑桥有高信号病变并伴有轻微水肿。两例均完全康复。积累更多与HPV疫苗接种存在时间关联的ADEM确诊病例的进一步数据很重要。
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