Sekiguchi Kenji, Yasui Naoko, Kowa Hisatomo, Kanda Fumio, Toda Tatsushi
Division of Neurology, Kobe University Graduate School of Medicine, Japan.
Intern Med. 2016;55(21):3181-3184. doi: 10.2169/internalmedicine.55.5472. Epub 2016 Nov 1.
We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.
我们在此报告两例接种人乳头瘤病毒（HPV）疫苗后发生急性播散性脑脊髓炎（ADEM）的病例。病例1在第二次接种卉妍康疫苗14天后出现复视并步态不稳。脑部磁共振成像（MRI）显示脑桥被盖部有一个孤立的小脱髓鞘病变。病例2在第二次接种加德西疫苗16天后出现发热和肢体感觉异常。脑部MRI在T2加权图像上显示脑桥有高信号病变并伴有轻微水肿。两例均完全康复。积累更多与HPV疫苗接种存在时间关联的ADEM确诊病例的进一步数据很重要。
