Winningham M L, MacVicar M G, Bondoc M, Anderson J I, Minton J P
Oncol Nurs Forum. 1989 Sep-Oct;16(5):683-9.
This study examined the effect of a supervised, aerobic exercise program on change in body weight and composition (multi-site subcutaneous skinfold measures, percent body fat, and lean body weight) of women undergoing adjuvant chemotherapy for breast cancer. Stage II patients with breast cancer (N = 24) were randomized to an exercise treatment group (EG, n = 12) and a control group (CG, n = 12). The EG participated in the individualized Winningham Aerobic Interval Training (WAIT) exercise program with exertional levels set at 60%-85% of maximal heart rate for 20-30 minutes, 3 times per week, for 10-12 weeks. The CG received no exercise treatment, but were asked to continue with their daily activities. Subjects were asked to maintain their customary eating patterns throughout their participation. Data were analyzed using covariate analysis, adjusting for age and pre-test values. Comparisons of pre- and post-test results indicated that exercise had a moderating effect on gain in body fat and altered the subcutaneous body fat profile in both obese (OB) and nonobese (NOB) subjects. Exercising OB subjects showed a greater increase in lean body weight than NOB subjects, indicating an increase in muscle tissue. Results from this study may be useful in designing safe and effective weight-control programs for patients with breast cancer on chemotherapy.
本研究探讨了一项有监督的有氧运动计划对接受乳腺癌辅助化疗的女性体重及身体成分变化（多部位皮下皮褶测量、体脂百分比和去脂体重）的影响。II期乳腺癌患者（N = 24）被随机分为运动治疗组（EG，n = 12）和对照组（CG，n = 12）。运动治疗组参与个性化的温宁厄姆有氧间歇训练（WAIT）运动计划，运动强度设定为最大心率的60%-85%，每次20-30分钟，每周3次，共10-12周。对照组未接受运动治疗，但被要求继续其日常活动。受试者在参与研究期间被要求保持其习惯的饮食模式。数据采用协变量分析进行分析，并对年龄和测试前值进行了校正。测试前和测试后结果的比较表明，运动对体脂增加有调节作用，并改变了肥胖（OB）和非肥胖（NOB）受试者的皮下体脂分布。与非肥胖受试者相比，进行运动的肥胖受试者去脂体重增加更多，表明肌肉组织有所增加。本研究结果可能有助于为接受化疗的乳腺癌患者设计安全有效的体重控制计划。
