Mahieu Mary A, Ramsey-Goldman Rosalind
Northwestern University Feinberg School of Medicine, Division of Rheumatology, 240 E. Huron St. Suite M-300, Chicago, IL 60611, United States.
Curr Rheumatol Rev. 2017;13(2):103-112. doi: 10.2174/1573397112666161029224953.
Fatigue impacts 80-90% of patients with systemic lupus erythematosus (SLE), and an incomplete understanding of fatigue mechanisms limits effective treatment. Disease activity indices and laboratory markers inconsistently correlate with fatigue severity in SLE populations. Identification of fatigue biomarkers has important implications for understanding pathogenesis and defining novel therapeutic targets, but a paucity of evidence exists for fatigue biomarkers in SLE. The evidence for adipokines, reduced glutathione, iron deficiency, and vitamin D as potential biomarkers for SLE-related fatigue are reviewed. To address gaps in the SLE literature, the experience of each fatigue biomarker in other diseases is examined. Finally, biomarker associations with SLE pathogenesis and disease activity are discussed, as further rationale for investigation among SLE patients.
疲劳影响80%至90%的系统性红斑狼疮（SLE）患者，而对疲劳机制的不完全理解限制了有效治疗。疾病活动指数和实验室指标与SLE人群的疲劳严重程度之间的相关性并不一致。识别疲劳生物标志物对于理解发病机制和确定新的治疗靶点具有重要意义，但SLE中疲劳生物标志物的证据却很少。本文综述了脂肪因子、还原型谷胱甘肽、缺铁和维生素D作为SLE相关疲劳潜在生物标志物的证据。为了填补SLE文献中的空白，研究了每种疲劳生物标志物在其他疾病中的情况。最后，讨论了生物标志物与SLE发病机制和疾病活动的关联，作为对SLE患者进行进一步研究的理由。
