Haseeb Muhammad Tahir, Hussain Muhammad Ajaz, Bashir Sajid, Ashraf Muhammad Umer, Ahmad Naveed
a Department of Pharmaceutics, Faculty of Pharmacy , University of Sargodha , Sargodha , Pakistan.
b Department of Chemistry , University of Sargodha , Sargodha , Pakistan.
Drug Dev Ind Pharm. 2017 Mar;43(3):409-420. doi: 10.1080/03639045.2016.1257017. Epub 2016 Nov 28.
Advancement in technology has transformed the conventional dosage forms to intelligent drug delivery systems. Such systems are helpful for targeted and efficient drug delivery with minimum side effects. Drug release from these systems is governed and controlled by external stimuli (pH, enzymes, ions, glucose, etc.). Polymeric biomaterial having stimuli-responsive properties has opened a new area in drug delivery approach.
Potential of a polysaccharide (rhamnogalacturonan)-based hydrogel from Linseeds (Linum usitatissimum L.) was investigated as an intelligent drug delivery material.
Different concentrations of Linseed hydrogel (LSH) were used to prepare caffeine and diacerein tablets and further investigated for pH and salt solution-responsive swelling, pH-dependent drug release, and release kinetics. Morphology of tablets was observed using SEM.
LSH tablets exhibited dynamic swelling-deswelling behavior with tendency to swell at pH 7.4 and in deionized water while deswell at pH 1.2, in normal saline and ethanol. Consequently, pH controlled release of the drugs was observed from tablets with lower release (<10%) at pH 1.2 and higher release at pH 6.8 and 7.4. SEM showed elongated channels in swollen then freeze-dried tablets.
The drug release was greatly influenced by the amount of LSH in the tablets. Drug release from LSH tablets was governed by the non-Fickian diffusion.
These finding indicates that LSH holds potential to be developed as sustained release material for tablet.
技术进步已将传统剂型转变为智能药物递送系统。此类系统有助于实现靶向、高效的药物递送，同时副作用最小。这些系统中的药物释放受外部刺激（pH值、酶、离子、葡萄糖等）的调控。具有刺激响应特性的聚合物生物材料为药物递送方法开辟了新领域。
研究了亚麻籽（亚麻）中基于多糖（鼠李半乳糖醛酸聚糖）的水凝胶作为智能药物递送材料的潜力。
使用不同浓度的亚麻籽水凝胶（LSH）制备咖啡因和双醋瑞因片剂，并进一步研究其对pH值和盐溶液的响应性溶胀、pH值依赖性药物释放及释放动力学。使用扫描电子显微镜观察片剂的形态。
LSH片剂表现出动态溶胀-消溶胀行为，在pH值7.4和去离子水中有溶胀趋势，而在pH值1.2、生理盐水和乙醇中则消溶胀。因此，观察到片剂的药物释放受pH值控制，在pH值1.2时释放较低（<10%），在pH值6.8和7.4时释放较高。扫描电子显微镜显示，溶胀后冻干的片剂中有细长通道。
片剂中LSH的量对药物释放有很大影响。LSH片剂的药物释放受非菲克扩散控制。
这些发现表明，LSH有潜力被开发为片剂的缓释材料。
