Gan Xin, Wang Xiaohui, Huang Yiwan, Li Guanghao, Kang Hao
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Biomedicines. 2024 Apr 22;12(4):923. doi: 10.3390/biomedicines12040923.
This review critically evaluates advancements in multifunctional hydrogels, particularly focusing on their applications in osteoarthritis (OA) therapy. As research evolves from traditional natural materials, there is a significant shift towards synthetic and composite hydrogels, known for their superior mechanical properties and enhanced biodegradability. This review spotlights novel applications such as injectable hydrogels, microneedle technology, and responsive hydrogels, which have revolutionized OA treatment through targeted and efficient therapeutic delivery. Moreover, it discusses innovative hydrogel materials, including protein-based and superlubricating hydrogels, for their potential to reduce joint friction and inflammation. The integration of bioactive compounds within hydrogels to augment therapeutic efficacy is also examined. Furthermore, the review anticipates continued technological advancements and a deeper understanding of hydrogel-based OA therapies. It emphasizes the potential of hydrogels to provide tailored, minimally invasive treatments, thus highlighting their critical role in advancing the dynamic field of biomaterial science for OA management.
本综述批判性地评估了多功能水凝胶的进展，尤其关注其在骨关节炎（OA）治疗中的应用。随着研究从传统天然材料发展而来，出现了向合成和复合水凝胶的重大转变，它们以卓越的机械性能和增强的生物降解性而闻名。本综述重点介绍了可注射水凝胶、微针技术和响应性水凝胶等新应用，这些应用通过靶向和高效的治疗递送彻底改变了OA治疗。此外，还讨论了创新的水凝胶材料，包括基于蛋白质的水凝胶和超润滑水凝胶，因其具有减少关节摩擦和炎症的潜力。还研究了将生物活性化合物整合到水凝胶中以增强治疗效果。此外，该综述预计技术将持续进步，并对基于水凝胶的OA疗法有更深入的了解。它强调了水凝胶提供定制化、微创治疗的潜力，从而突出了它们在推动用于OA管理的生物材料科学这一动态领域中的关键作用。
