Kirby D A, Verrier R L
Cardiovascular Laboratories, Harvard School of Public Health, Boston, MA 02115.
Physiol Behav. 1989 May;45(5):1017-20. doi: 10.1016/0031-9384(89)90231-x.
We have demonstrated in a previous study that in the normal heart REM sleep induces surges in heart rate and coronary blood flow which are abolished by bilateral stellectomy. To study the effects of sleep in the stenosed coronary circulation, dogs were instrumented with Doppler flow probes and hydraulic occluders around the left circumflex coronary artery to measure coronary blood flow and to produce a 60% flow reduction. Catheters were placed in the aorta to measure mean arterial blood pressure. Electrodes were implanted via the frontal sinus to identify sleep stages. In the absence of stenosis, mean blood pressure was 95 +/- 3 mmHg, HR was 111 +/- 4 bpm, and coronary blood flow was 33 +/- 2 ml/min. During stenosis, REM induced episodic increases in heart rate which were accompanied by 38% decreases in coronary blood flow. We conclude that in the stenosed coronary circulation, REM sleep produces episodic sinus tachycardia and coronary blood flow reduction.
我们在先前的一项研究中已经证明，在正常心脏中，快速眼动睡眠会引起心率和冠状动脉血流量的激增，而双侧星状神经节切除术可消除这种现象。为了研究睡眠对狭窄冠状动脉循环的影响，给狗在左旋冠状动脉周围安装了多普勒血流探头和液压阻塞器，以测量冠状动脉血流量并使血流量减少60%。将导管插入主动脉以测量平均动脉血压。通过额窦植入电极以识别睡眠阶段。在没有狭窄的情况下，平均血压为95±3 mmHg，心率为111±4 bpm，冠状动脉血流量为33±2 ml/min。在狭窄期间，快速眼动睡眠引起心率阵发性增加，同时冠状动脉血流量减少38%。我们得出结论，在狭窄的冠状动脉循环中，快速眼动睡眠会导致阵发性窦性心动过速和冠状动脉血流量减少。
