Zhang Hong-Jie, Li Wan-Fei, Fong Harry H S, Soejarto Djaja Doel
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA.
Molecules. 2016 Oct 31;21(11):1448. doi: 10.3390/molecules21111448.
The International Cooperative Biodiversity Groups (ICBG) Program based at the University of Illinois at Chicago (UIC) is a program aimed to address the interdependent issues of inventory and conservation of biodiversity, drug discovery and sustained economic growth in both developing and developed countries. It is an interdisciplinary program involving the extensive synergies and collaborative efforts of botanists, chemists and biologists in the countries of Vietnam, Laos and the USA. The UIC-ICBG drug discovery efforts over the past 18 years have resulted in the collection of a cumulative total of more than 5500 plant samples (representing more than 2000 species), that were evaluated for their potential biological effects against cancer, HIV, bird flu, tuberculosis and malaria. The bioassay-guided fractionation and separation of the bioactive plant leads resulted in the isolation of approximately 300 compounds of varying degrees of structural complexity and/or biological activity. The present paper summarizes the significant drug discovery achievements made by the UIC-ICBG team of multidisciplinary collaborators in the project over the period of 1998-2012 and the projects carried on in the subsequent years by involving the researchers in Hong Kong.
国际合作生物多样性小组（ICBG）项目设在伊利诺伊大学芝加哥分校（UIC），该项目旨在解决发展中国家和发达国家生物多样性清查与保护、药物研发以及经济持续增长等相互关联的问题。这是一个跨学科项目，涉及越南、老挝和美国三国的植物学家、化学家和生物学家的广泛协同合作与共同努力。在过去18年里，UIC-ICBG的药物研发工作累计收集了超过5500份植物样本（代表2000多种物种），并对这些样本针对癌症、艾滋病毒、禽流感、结核病和疟疾的潜在生物效应进行了评估。通过生物测定指导的生物活性植物提取物的分级分离，共分离出约300种结构复杂性和/或生物活性各异的化合物。本文总结了1998年至2012年期间UIC-ICBG多学科合作团队在该项目中取得的重大药物研发成果，以及随后几年通过香港研究人员参与开展的项目成果。
