Libman Amey, Zhang Hongjie, Ma Cuiying, Southavong Bounhong, Sydara Kongmany, Bouamanivong Somsanith, Tan Ghee T, Fong Harry H S, Soejarto D Doel
Program for Collaborative Research in the Pharmaceutical Sciences, M/C 781, Department of Medical Chemistry & Pharmacognosy, College of Pharmacy, the University of Illinois, Chicago, Illinois 60612, USA ; Biology Department, Bradly University, Peoria, IL 61625, USA.
Asian J Tradit Med. 2008;3(6):203-210.
As a part of the UIC-based ICBG project in Laos, plants were collected based on ethnomedical interviews and evaluated for antimalarial activity. A CHCl extract from the vine of (Wall.) Decne. (Asclepiadaceae) showed promising anti-malarial activity while exhibiting low levels of cytotoxicity and was thus followed up with further fractionation and biological evaluation. Bioassay-guided fractionation led to the isolation of a new steroidal glycoside, gongroneside A, which showed antimalarial activity with an IC value of 1.60 and 1.39 μM against the D6 and W2 clones, respectively.
作为基于美国伊利诺伊大学芝加哥分校（UIC）在老挝开展的国际合作生物多样性小组（ICBG）项目的一部分，依据民族医学访谈采集植物样本，并对其抗疟活性进行评估。从（萝藦科）（Wall.）Decne.的藤本植物中提取的氯仿提取物显示出有前景的抗疟活性，同时细胞毒性水平较低，因此对其进行了进一步的分离和生物学评估。生物测定导向的分离过程导致分离出一种新的甾体糖苷，贡龙苷A，它对D6和W2克隆的抗疟活性IC值分别为1.60和1.39 μM。
