Wei Yao, Gong Jianfeng, Zhu Weiming, Tian Hongliang, Ding Chao, Gu Lili, Li Ning, Li Jieshou
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 21002, China.
BMC Microbiol. 2016 Nov 3;16(1):255. doi: 10.1186/s12866-016-0869-2.
Fecal microbiota transplantation (FMT) induces remission in ulcerative colitis (UC). However, the treatment effect of FMT diminishes over time. Maintaining the diversity of the gut flora for long periods may improve the effects of FMT in UC. Pectin, which can be fermented by gut microbiota into short-chain fatty acids, is postulated to shape the composition and maintain the balance of gut microbiota following transplantation. This study investigated whether pectin could enhance the effects of FMT in UC patients.
Three FMT patients and four FMTP patients achieved the primary outcome. The Mayo scores of the FMTP group were lower than those of the FMT group at weeks 4 and 12 (P = 0.042 and P = 0.042, respectively). There were no differences in the diversity of the gut flora between the two groups at weeks 4 and 12; however, the composition of the gut flora of the FMTP group was more similar than the FMT group to that of the donor at all-time points post-treatment.
Pectin decreased the Mayo score by preserving the diversity of the gut flora following FMT for UC.
Current Controlled Trial NCT02016469 . Registered 10 November 2013.
粪便微生物群移植（FMT）可诱导溃疡性结肠炎（UC）缓解。然而，FMT的治疗效果会随着时间推移而减弱。长期维持肠道菌群的多样性可能会提高FMT对UC的治疗效果。果胶可被肠道微生物群发酵成短链脂肪酸，据推测，它在移植后可塑造肠道微生物群的组成并维持其平衡。本研究调查了果胶是否能增强FMT对UC患者的治疗效果。
3例接受FMT的患者和4例接受FMT联合果胶（FMTP）的患者达到了主要结局。在第4周和第12周时，FMTP组的梅奥评分低于FMT组（分别为P = 0.042和P = 0.042）。在第4周和第12周时，两组肠道菌群的多样性无差异；然而，在治疗后的所有时间点，FMTP组肠道菌群的组成比FMT组更接近供体。
果胶通过在UC患者接受FMT后维持肠道菌群的多样性降低了梅奥评分。
当前受控试验NCT02016469。于2013年11月10日注册。
