疼痛的神经回路：最新进展与当前观点
Neural circuits for pain: Recent advances and current views.
作者信息
Peirs Cedric, Seal Rebecca P
机构信息
Departments of Neurobiology and Otolaryngology, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, BST3, Pittsburgh, PA 15213, USA.
Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
出版信息
Science. 2016 Nov 4;354(6312):578-584. doi: 10.1126/science.aaf8933.
Abstract
The mammalian nervous system encodes many different forms of pain, from those that arise as a result of short-term low-grade interactions with noxious thermal, chemical, or mechanical sources to more serious forms of pain induced by trauma and disease. In this Review, we highlight recent advances in our understanding of the neural circuits that encode these types of pain. Promising therapeutic strategies based on recent advances are also highlighted.
摘要
哺乳动物的神经系统编码多种不同形式的疼痛，从因与有害热、化学或机械源进行短期低度相互作用而产生的疼痛，到由创伤和疾病引起的更严重的疼痛形式。在本综述中，我们重点介绍了我们对编码这些疼痛类型的神经回路理解的最新进展。还重点介绍了基于这些最新进展的有前景的治疗策略。
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