a Department of Laboratory Medicine , Cleveland Clinic , Cleveland , OH , USA.
b Division of Infectious Diseases , Assaf Harofeh Medical Center , Zerifin , Israel.
Virulence. 2017 May 19;8(4):417-426. doi: 10.1080/21505594.2016.1255381. Epub 2016 Nov 4.
The global spread of carbapenem-resistant Enterobacteriaceae (CRE) has been fostered by the lack of preemptive screening of patients in healthcare facilities that could prevent patient-to-patient transmission. Outbreaks of CRE infections have led some institutions to implement rigorous screening programs, although controlled comparative data are frequently lacking. Resource limitations and uncertainty regarding the optimal approach has kept many facilities from enacting more active routine surveillance policies that could reduce the prevalence of CRE. The ideal population to target for screening, the frequency of testing, and the preferred test method are components of surveillance programs that remain open to debate. This review discusses the rationale for different screening policies in use and the performance characteristics of laboratory methods available to detect CRE carriage.
全球范围内碳青霉烯类耐药肠杆菌科（CRE）的传播是由于医疗机构未能对患者进行抢先筛查，从而导致患者之间的传播。CRE 感染的爆发导致一些机构实施了严格的筛查计划，尽管经常缺乏对照数据。资源限制以及对最佳方法的不确定性使得许多机构无法实施更积极的常规监测政策，从而降低 CRE 的流行率。用于筛查的理想人群、检测频率和首选检测方法是监测计划的组成部分，这些计划仍存在争议。这篇综述讨论了不同筛查政策的基本原理以及用于检测 CRE 携带的实验室方法的性能特征。
